University of California

Other

Mark J Mannis

Christopher John Murphy

Ted W Reid

Michael E Selsted

Robert I Lehrer

Tomas Ganz

James S Cullor

Erik R Wisner

John H Doval

Kaitlin Murphy

Bradley A Foster

The present invention relates to a deformable object to be implanted into a surgical site (exemplified by but not limited to a cornea lenticule, e.g., that could be native corneal tissue or a synthetic or biosynthetic construct), surgical instrumentation for altering the curvature and arc length of the deformable object to be implanted (e.g. corneal lenticule), as well as methods for introduction of the deformable object into the specifically prepared wound bed and for introduction of the deformable object.

Implanting oversized objects into surgical beds

Healing of wounds in mammalian tissue may be enhanced by the application of certain neuropeptides, optionally in combination with known growth promoting hormones. Exemplary neuropeptides include tachykinins, such as substance P, substance K, and the like, as well as calcitonin gene-related peptides. The compositions include a carrier or vehicle suitable for topical application and are utilized by applying to the site of the wound. Wounds resulting from trauma, surgery, and disease may be treated. The compositions promote elaboration of cellular matrices and development of cellular attachment mechanisms in addition to stimulating cellular proliferation.

Methods and compositions using substance P to promote wound healing

A method for treating cutaneous and corneal wounds as well as certain microbial-related diseases comprises topically applying a defensin peptide to the affected tissue. The compositions comprise a natural, synthetic, or analog defensin molecule having both a mitogenic activity capable of stimulating cell growth and an antimicrobial activity capable of inhibiting the growth of a wide variety of pathogens. In addition to therapeutic use, the defensins are useful as mitogens in cell and tissue culture media.

Defensin peptide compositions and methods for their use

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Carmichael, CA, United States of America

Mark J Mannis