Beckman Coulter, Inc.

Mark J Kittock

Humayun Qureshi

Brian D Wilson

Robert J Mattila

Peter G Werness

Armer J Willenbring

Glenn A Davis

Donald J Gjerdingen

A new method and system for transporting and sorting multiple reagent packs used in conjunction with an immunodiagnostic instrument is provided. The new system includes a multiplicity of reagent packs; a gantry movably mounted on a rack structure for carrying a gripper mechanism, wherein the gripper mechanism has gripping jaws for engagement with the reagent pack; a power assembly for actuating the respective movement of the gantry, the gripper mechanism and the gripping jaws; a storage nest having a multiplicity of compartments, each adapted for storing a one of the respective reagent packs; and a pipetting nest having a multiplicity of compartment, each adapted for retaining a respective one of the reagent packs for simultaneous pipetting. Methods of using the system and a novel reagent pack used in connection with the new system are also provided.

Method and system for transporting and storing multiple reagent packs and reagent packs used therein

A rotary incubation station for an automated analyzer is provided. The rotary incubation station includes a platform, a circular ring-shaped outside rotary wheel having a plurality of nesting locations for washing and reading vessels, and a circular disc-shaped inside rotary wheel having a plurality of nesting locations for incubation and storage of vessels. The rotary incubation station also includes a spur gear mechanism for rotating the outside and inside rotary wheels, including spur gear drivers respectively engaged with spur gear teeth of the outside and inside rotary wheel, providing accurate control of the rotation of the outside and inside rotary wheels.

Rotary incubation station for immunoassay systems

A method and system for picking and placing vessels are provided. The system includes a gripper assembly mounted on a positioning mechanism. The gripper assembly includes a cylinder, a plurality of flexible gripping members extending from the cylinder in a spaced-apart relationship for receiving therebetween a vessel and holding it by friction, a piston slideably inserted inside the cylinder, and a plunger connected to and movable with the piston and extending between the gripping members for engaging the vessel. The method includes the steps of positioning the gripper assembly, picking up and transferring a vessel, and placing, seating and releasing the vessel. The contents of the vessel may also be mixed simultaneously during the transferring of the vessel.

Method and system for picking and placing vessels

A clearance seal assembly is disclosed. The assembly comprises a stationary member defining a first side, a second side and an opening connecting the first and second side; a moving member moveably disposed through the opening; and a sealing member circumferentially disposed between the stationary member and the moving member. The sealing member has a fluid-tight relationship with the stationary member. The sealing member and the moving member define a continuous and uniform gap having a size that allows the fluid to fill the gap but prevents the fluid from flowing through the gap from the first side to the second side of the opening under an operating pressure differential between the first and the second side. In a preferred embodiment, both the sealing member and the moving member are made of a ceramic material. The sealing assembly may also include a static seal disposed between the stationary member and the sealing to allow a variable clearance therebetween while maintaining the fluid-tight relationship between the sealing member and the stationary member. A pump utilizing the sealing assembly of the present invention is also disclosed.

Fluid-moving device with a clearance seal

A method and system for automated immunochemistry or chemistry analysis are provided. The method and system provide a sample aliquoting section, a reagent pipetting section having a plurality of independent reagent pipetting stations, each operating on a cycle of a first period of time, and an incubate and wash and read section operating on a cycle of a second period of time to match the throughput of the system, where the quotient of the first period of time divided by the second period of time is a whole number, and the number of the independent reagent pipetting stations being equal to the whole number. The respective cycles of the independent reagent pipetting stations are staggered apart by the second time period, such that at least one of the multiple independent pipetting stations is available for working with the incubate and wash and read section at each operating cycle of the second period of time.

Method and system for automated immunochemistry analysis

A fluid-moving device with an integrated valve is disclosed. The device includes a housing defining a suction chamber and at least one internal passageway formed inside the housing. A first end of the internal passageway opens to the suction chamber and a second end of the internal passageway connects to an outside surface of the housing. The fluid-moving device of the present invention also includes a pumping structure disposed inside the suction chamber for generating a pressure inside the suction chamber. The device may also include valve passageways formed inside the housing. In one embodiment, a manifold is utilized for connecting the valve passageways to fluid supplies and fluid sinks. The manifold has a casing, at least one input port, at least one output port, and a plurality of internal manifold passageways formed in the manifold casing. A method of making a fluid-moving device with an integrated valve of the present invention is also disclosed.

Growing community of inventors

Eden Prairie, MN, United States of America

Mark J Kittock