University of Michigan

Mark J Kiel

Sean J Morrison

Omer Yilmaz

Toshihide Iwashita

Kojo Elenitoba-Johnson

Megan Lim

Thirunavukkarasu Velusamy

Delphine Rolland

Nathanael G Bailey

Bryan L Betz

Omer H Yilmaz

Sean Morrison

Provided herein are kits, compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent gene fusions (e.g., recurrent translocations involving TYK2) as diagnostic markers and clinical targets for cutaneous CD30-positive lymphoproliferative disorders (e.g., lymphomatoid papulosis; primary cutaneous anaplastic large cell lymphoma).

Recurrent gene fusions in cutaneous CD30-positive lymphoproliferative disorders

A data analysis method and computer system electronically mines published articles from existing medical literature sources to discover associations that may exist between various diseases and various genes and/or gene mutations or other genetic changes. The method and system then organizes, categorizes and prioritizes the discovered associations in accordance with the strength of evidence supporting these associations. The resulting information can then be integrated into the processing of genome sequencing data to more quickly determine what genome sequencing data is of most relevance for clinical decision makings.

Systems and methods for electronically mining genomic data

The present invention relates to methods of identifying, collecting and isolating hematopoietic stem cells (HSCs) and compositions of purified HSCs. Specifically, the present invention provides methods of isolating and purifying CD150HSCs, CD48HSCs, and CD244HSCs. The present invention also relates to purified cell samples with enriched CD150HSCs, CD48HSCs, and CD244HSCs populations, as well as methods of treating subjects with such compositions.

Hematopoietic stem cell identification and isolation

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Ann Arbor, MI, United States of America

Mark J Kiel