University of Pennsylvania

Valorisation-Recherche, Societe En Commandite

University of Illinois

Institut De Recherches Cliniques De Montreal

Mark J Holterman

David B Weiner

Michael Agadjanyan

Rafick P Sekaly

Bellur S Prabhakar

Chenthamarakshan Vasu

Matthew N Meriggioli

Improved vaccines and methods of using the same are disclosed Immunosuppressive compositions for treating individuals who have autoimmune diseases or transplants and methods of using the same are disclosed.

Mutant human CD80 and compositions for and methods of making and using the same

GM-CSF administered before immunization exerted a sustained suppressive effect against the induction of myasthenia gravis (MG). This suppression was associated with lowered serum autoantibody levels, reduced T cell proliferative responses to AChR, and an expansion in the population of FoxP3+ regulatory T cells. Manipulating DCs to expand regulatory T cells is useful for the control of autoimmune diseases such as myasthenia gravis MG.

Uses of bispecific antibody coated dendritic cells pulsed with antigens and GM-CSF in immune regulation

Nucleic acids encoding mutant human CD80 and compositions comprising the same

Growing community of inventors

River Forest, IL, United States of America

Mark J Holterman