The Dow Chemical Company

Dow Global Technolgoies LLC

Mark J Hall

Nicholas S Grasman

Steven J Guillaudeu

Donald A Tomalia

Stephen R Betso

Matthias Knarr

Meinolf Brackhagen

Steven R Jenkins

Robert L Schmitt

Michael D Read

Kun S Hyun

Karen A Coppens

Joseph R Powers

Uma Shrestha

True L Rogers

Jin Zhao

John A Naumovitz

Donald E Kirkpatrick

James A Stevenson

Duane F Foye

Paul T Louks

Wesley J Spaulding

Kevin P O'donnell

Pamela S Larsen

Shawn A Mitchell

William A Wood

Maureen L Rose

William W Porter, Iii

A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa&#xb7;s, measured as a 2 wt.-% solution in water at 20&#xb0; C., is stable over an extended time period. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying. Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa&#xb7;s and optionally one or more adjuvants.

Composition comprising an organic liquid diluent and a cellulose ether of very low viscosity

A solid dispersion comprising at least one active ingredient in at least one hydroxyalkyl methylcellulose having a DS of from 1.0 to 2.7 and an MS of from 0.40 to 1.30, wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxyalkoxyl groups, can be produced by extrusion or spray-drying.

Solid dispersion comprising a highly substituted hydroxyalkyl methylcellulose

An injection-molded shell of a dosage form of good quality is producible by a) providing a composition comprising i) from 25 to 90 weight percent of ethylcellulose, ii) from 7.5 to 60 weight percent of a polysaccharide or polysaccharide derivative being different from ethylcellulose, and iii) from 2.5 to 50 weight percent of at least one component being different from polysaccharides and polysaccharide derivatives, based on the total weight of the composition, with the proviso that the composition comprises zero or not more than 10 weight percent of gelatin and zero or not more than 10 weight percent of a polymer comprising homo- or copolymerized acrylic acid, homo- or copolymerized methacrylic acid, a homo- or copolymerized acrylate or a homo- or copolymerized methacrylate, and b) subjecting the composition to shearing and heat to plasticize the composition and injection-molding the plasticized composition into a three-dimensional shell of a dosage form.

Injection-molded dosage form

A biologically active composition comprising an ethylcellulose, a polyethylene oxide and a biologically active ingredient, wherein the amount of ethylcellulose is at least about (15) percent, based on the total weight of the composition, can be used in melt-extrusion processes to produce pharmaceutical dosage forms.

Biologically active composition comprising ethylcellulose

The present invention is a coated particulate in the form of a powder or in the form of a pellet, the particulate comprising a vinylidene chloride interpolymer and being coated with at least one processing aid at a level effective to improve the extrudability of the vinylidene chloride interpolymer. The processing aid beneficially is selected from the group consisting of fatty esters; wax esters; glycerol esters; glycol esters; fatty alcohol esters, fatty alcohols; fatty amides; metallic salts of fatty acids; olefin polymers and polyolefin waxes.

Extrudable thermoplastic particulates

An improved stabilizer concentrate for use in stabilizing polymeric blend compositions which comprise a thermally sensitive interpolymer. The stabilizer concentrate comprises a carrier resin, and a stabilizing agent capable of stabilizing a thermally sensitive interpolymr. The improvement comprises employing a carrier resin having a viscosity such that the stabilizer concentrate has a viscosity of less than 60 percent of the viscosity of the polymeric blend composition.

Stabilizer concentrate

The present invention is a formulated barrier composition containing tetrasodium pyrophosphate or magnesium hydroxide, high density polyethylene, epoxidzed vegetable oil, oxidized polyolefin and a paraffin or polyolefin wax. The composition has a substantially lower oxygen permeability than existing compositions and is at least equally extrudable.

Formulation for extrudable vinylidene chloride copolymers having high

An improved stabilizer concentrate for use in stabilizing polymeric blend compositions which comprise a thermally sensitive interpolymer. The stabilizer concentrate comprises a carrier resin, and a stabilizing agent capable of stabilizing a thermally sensitive interpolymer. The improvement comprises employing a carrier resin having a viscosity such that the stabilizer concentrate has a viscosity of less than 60 percent of the viscosity of the polymeric blend composition.

A process for improving the extrudability of a vinylidene chloride interpolymer pellet. A vinylidene chloride interpolymer pellet displaying a first endotherm, as determined by differential scanning calorimetry according to American Society of Testing and Materials Test Method D-3417, below 75.degree. Celsius is exposed to a temperature above about 55.degree. Celsius for a length of time sufficient to raise said first endotherm to 75.degree. Celsius or above. Pellets treated in such a manner possess improved extrudability.

Vinylidene chloride interpolymer possessing improved extrudability

Star/comb-branched polyamides having good resistance to degradation upon exposure to shear are prepared by reacting polyvalent core compounds such as tribromoneopentyl alcohol with an oxazoline such as 2-ethyl-2-oxazoline to provide the desired polyamide. The polyamides are readily hydrolyzed with acid such as hydrochloric acid to form star/comb-branched polyamines. The polyamides and the polyamines are useful as viscosity enhancing agents in such applications as paints, mobility control agents and hydraulic fluids.

Star/comb-branched polyamine

Star/comb-branched polyamide

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Midland, MI, United States of America

Mark J Hall