USA As Represented by Secretary of the Navy

Mark J Feldstein

Frances S Ligler

Joel P Golden

Brian D MacCraith

Chris A Rowe

The present invention provides a fluidics system and a method for selectively drawing fluid from at least one selected reservoir into a channel by providing a negative pressure source downstream of the fluid and channel and selectively back filling the selected reservoir with a gas.

Fluidics system

A multimode waveguide device for assays includes a multimode waveguide with a patterned, reflective surface coating. The exposed portion or portions of the reflectively coated waveguide surface are for analyte recognition. A fluidics cell is attached to the waveguide so that the channel or channels of the fluidics cell match with the exposed portion or portions of the waveguide surface. The channel or channels direct one or more sample fluids over the exposed portion or portions of the waveguide surface. The reflective coating minimizes loss and scattering of excitation and fluorescence light during a fluorescence assay.

Reflectively coated optical waveguide and fluidics cell integration

A waveguide-based sensing system includes a plurality of waveguides secured within a waveguide holder. Each waveguide has a sensing surface with athed analyte recognition elements. The end faces of the sensing surfaces are perpendicular (or at least approximately perpendicular) to the sensing surfaces. The sensing surfaces are directly excited by light directed normal thereto and emit optical signals responsive to the presence of an analyte. These optical signals are coupled into the waveguides. The optical signals travel along the length of the waveguides to the end surfaces, which integrate the optical signals over the length of the waveguides. The integrated optical signals emitted from the end surfaces of the fibers are then detected and analyzed.

Growing community of inventors

Washington, DC, United States of America

Mark J Feldstein