Isp Investments Inc.

Mark J Cooney

Satish C Nigam

Jonathan Caudill

Paul D Taylor

Krishnamurthy Nacharaju

Larry A Crabtree

A process for the synthesis of linear &#x3b1;,&#x3c9;-diolefins from an allylic substrate comprises the steps of a) forming the bis-Grignard reagent XMgCH(CH)CHMgX from an &#x3b1;,&#x3c9;-acyclic dihalide with X being a halogen; b) preparing a solution comprising an allylic substrate and a copper catalyst; c) catalyzing a coupling reaction by adding to the solution of step (b) the bis-Grignard reagent of step (a); and d) isolating and purifying the &#x3b1;,&#x3c9;-olefin coupling reaction product.

Method for the production of &#x3b1;, &#x3c9;-olefins by using the copper catalyzed coupling reaction of a Grignard reagent with an allylic substrate

Methods for the preparation of pharmaceutically acceptable organic or inorganic salts of 5-methylpyrazinecarboxylic acid-4-oxide esters including tris(hydroxymethyl)aminomethanol, N,N-dimethylethanolamine, N-methyl-D-glucamine, L-Lysine, L-arginine, Na, K, Ca and Mg. The esters of 5-methylpyrazinecarboxylic acid-4-oxide are oxidized in aqueous hydrogen peroxide at a pH of 2.5 to 7 in the presence of a catalyst selected from the group consisting of sodium tungstate, tungstic acid and ammonium heptamolybdate. The salts are formed by saponification of the esters followed by alcohol precipitation, or by reaction with a metal trimethylsilanoate, or by the reaction of organic bases with the saponified acids.

Pharmaceutically acceptable inorganic and organic salts of 5-methylpyrazine-2-carboxylic acid-4-oxide

Methods for the preparation of pharmaceutically acceptable salts of 5-methylpyrazine-carboxylic acid-4-oxide by using the oxidizing agent OXONE&#xae; for the N-oxidation of Cmethylpyrazinecarboxylic acid esters. The pharmaceutically acceptable salts are then formed by the saponification of the esters followed by alcohol precipitation.

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Circleville, OH, United States of America

Mark J Cooney