Cancer Research Technology Limited

University of London

University of Kent

Mark Howard

John Marshall

Danielle Dicara

Danielle DiCara

Ahuva Nissim

The present disclosure provides a method for generating an affinity reagent library against a target protein which interacts with a ligand, which comprises the following steps; &#x2022;i) determining one or more structural element(s) of the ligand which are involved in ligand: target protein interaction; &#x2022;ii) producing a library of peptides which retain these structural element(s); and &#x2022;iii) grafting each peptide from the library of peptides into a portion of the affinity reagent molecule such that it may interact with the target protein, in order to produce an affinity reagent library.

Method for generating an affinity reagent library

AV&#x3b2;6 peptide ligands, functional variants thereof and their nucleic acids encoding them are disclosed with their uses in the treatment and imaging of AV&#x3b2;6 mediated diseases.

&#x3b1;v&#x3b2;6 peptide ligands and their uses

Growing community of inventors

Kent, United Kingdom

Mark Howard