National Research Council of Canada

University of Manitoba

Dalhousie University

Novadaq Technologies Ulc

Mark Hewko

Robert W Flower

Gurpreet Mangat

John C Docherty

Seshadri M Chari

Lorenzo Leonardi

Henry H Mantsch

Michael G Sowa

Jerl Payette

Bernhard J Schattka

Lin-P'ing Choo-Smith

Alex C T Ko

Blaine Cleghorn

Cecilia Dong

John C Doherty

Method for assessing the patency of a patient's blood vessel, advantageously during or after treatment of that vessel by an invasive procedure, comprising administering a fluorescent dye to the patient; obtaining at least one angiographic image of the vessel portion; and evaluating the at least one angiographic image to assess the patency of the vessel portion. Other related methods are contemplated, including methods for assessing perfusion in selected body tissue, methods for evaluating the potential of vessels for use in creation of AV fistulas, methods for determining the diameter of a vessel, and methods for locating a vessel located below the surface of a tissue.

Method and apparatus for performing intra-operative angiography

A non-invasive method of characterizing burn injuries using near infrared spectroscopy is described. In the method, a beam of light is emitted into the burnt tissue portion at two or more different tissue depths. The spectra are then compared using multivariate analysis to determine diagnostic regions of the spectra. This information is used to categorize the burn. In some cases, the diagnostic regions correspond to wavelengths related to the hemodynamics of the tissue portion. The spectra can also be repeated over time, thereby allowing trends and changes in the spectra to be measured. This data is in turn used to categorize the burn as either a superficial burn, partial thickness burn, deep partial burn or a full thickness burn. Once the burn has been categorized, the clinician can intervene as needed to treat the burn.

Visible-near infrared spectroscopy in burn injury assessment

Early dental caries detection is carried out by a method that combines optical coherence tomography (OCT) and Raman spectroscopy to provide morphological information and biochemical specificity for detecting and characterizing incipient carious lesions found in extracted human teeth. OCT imaging of tooth samples demonstrated increased light back-scattering intensity at sites of carious lesions as compared to the sound enamel. Raman microspectroscopy and fibre-optic based Raman spectroscopy are used to characterize the caries further by detecting demineralization-induced alterations of enamel crystallite morphology and/or orientation. OCT imaging is useful for screening carious sites and determining lesion depth, with Raman spectroscopy providing biochemical confirmation of caries. The combination is incorporated into a common probe operable without movement to scan the tooth surface and to provide an output for the dentist.

Detection and monitoring of changes in mineralized tissues or calcified deposits by optical coherence tomography and Raman spectroscopy

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Winnipeg, Canada

Mark Hewko