University of Texas System

Mark Hellmich

Jia Zhou

Csaba Szabo

In certain aspects the methods comprise administering an inhibitor of hydrogen sulfide biosynthesis, a cystathionine-&#x3b2;-synthase (CBS) inhibitor, or a hydrogen sulfide neutralizing agent to a patient having a cancer associated with elevated production of hydrogen sulfide.

Use of hydrogen sulfide synthesis inhibitors for cancer therapy

Certain embodiments are directed to apigenin analogues or derivatives. In certain aspects, the derivatives are developed as cystathionine-beta-synthase (CBS) inhibitors. In certain aspects, the derivatives are used as anticancer or anti-inflammatory agents. Certain embodiments are directed methods of treating or compositions used to treat fibrosis and cancers. In certain aspects one or more compounds described herein can be administered to a subject to treat pancreatic fibrosis, liver fibrosis, pancreatic cancer, colon cancer, breast cancer, brain tumors, head/neck cancer, prostate and lung cancers as well as other inflammation.

Growing community of inventors

Galveston, TX, United States of America

Mark Hellmich