Paratek Pharmaceuticals, Inc.

Mark Grier

Beena Bhatia

Todd Bowser

Mark L Nelson

Oak K Kim

Tadeusz Warchol

Joel Berniac

Kwasi Ohemeng

Jingwen Pan

Mark Nelson

Stuart B Levy

Mohamed Y Ismail

Laura Honeyman

Michael N Alekshun

Farzaneh Seyedi

Haregewein Assefa

Atul K Verma

Jackson Chen

Brent L Podlogar

Paul Abato

Victor Amoo

Rachid Mechiche

Jude Mathews

Oak Kim

The present invention pertains, at least in part, to novel substituted etracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.

Substituted tetracycline compounds

Methods of synthesizing substituted tetracycline compounds are provided.

Methods for synthesizing substituted tetracycline compounds

The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.

4-substituted tetracyclines and methods of use thereof

Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

Transcription factor modulating compounds and methods of use thereof

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Watertown, MA, United States of America

Mark Grier