Medtronic Ardian Luxembourg S.a.r.l.

Chf Solutions, Inc.

Backbeat Medical, Inc.

Ardian, Inc.

Respicardia, Inc.

Axon Therapies, Inc.

Plc Medical Systems, Inc.

Cibiem, Inc.

Zoll Respicardia, Inc.

Medtronic Ireland Manufacturing Unlimited Company

Reprieve Cardiovascular, Inc.

The Johns Hopkins University

Revivant Corporation

Gambro Lundia Ab

Zoll Circulation, Incorporated

Mark Gelfand

Howard R Levin

Denise Marie Zarins

Hanson Gifford

Howard Levin

Mark E Deem

Douglas Sutton

John J O'Mahony

Benjamin J Clark

Erik Thai

Nicolas Zadno

Mark S Leung

Andrew Victor Halpert

Denise M Demarais

Karun D Naga

Roman Turovskiy

Zoar Jacob Engelman

Dorin Panescu

Randy W Westlund

Neil Samuel Rothman

Brian Kelly

Edward G Rychlick

Eric Ryba

Luke Hughes

Danny Donovan

Naomi Buckley

Andrew H Wu

Kristofer J James

John Kelly

Stephen Nash

Fiachra Sweeney

Hans-Dietrich Polaschegg

Steven J Bernard

Grace Kelly

Lana Woolley

Barry Mullins

Michael Cummins

Vincenzo Tilotta

Antonis Panteleon

Todd P Goblish

Mark Tauscher

Gary Kelly

Arye Rosen

Mark C Lynn

Gwenda McMullin

Michael Turovskiy

Charles Lennox

Neil Chand Barman

Martin Maitre Grasse

Paul A Sobotka

Simplicio Velilla

Shashank Raina

Gwenda Francis

Henry R Halperin

Tamara Colette Baynham

Brett Daniel Schleicher

Robert I Rudko

Edwin B Merrick

Ary S Chernomorsky

Daniel Burkhoff

Joshua E Tsitlik

Gary P Kelly

Antonios Panteleon

Steve Bernard

Myron L Weisfeldt

Jayne B Merrick, Legal Representative

Marat Fudim

Seamus Ledwith

Hanson S Gifford, Iii

Veijo T Suorsa

Yegor D Sinelnikov

Kenneth M Martin

Francesco Piccagli

Harikrishna Tandri

Micheal Moriarty

Ronan Wood

Kreg George Gruben

Zoar Engelman

Jeff Koepsell

Lana Wooley

John O'Mahoney

Andrew Hal Pert

Andy Halpert

Denise Demarals

A means for treating breathing disorders by stimulating respiratory muscles or nerves to entrain respiratory systems while leaving respiratory drive intact. Embodiments of the invention employ frequency analysis to determine if appropriate stimulation energy is being applied.

Systems for treating disordered breathing by comparing stimulated and unstimulated breathing

A method to treat a human patient including: advancing a catheter through a natural airway of the patient and positioning a distal portion of the catheter in the natural airway of a lung of the patient to a target region in the lung, injecting a conductive hypertonic saline solution having a concentration of at least 5% of sodium chloride by weight/volume from the distal portion of the catheter into the target region; delivering energy from the distal portion into the conductive hypertonic saline solution in the target region, wherein the energy heats the liquid in the portion of the airway, and ablating the target region with the heated liquid.

Devices and methods for treating lung tumors

Microwave catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a microwave transmission element to a renal artery via an intravascular path. Renal neuromodulation may be achieved via dielectric heating in the presence of microwave irradiation that modulates neural fibers that contribute to renal function or alters vascular structures that feed or perfuse the neural fibers.

Catheter apparatuses, systems, and methods for neuromodulation

A method to treat patients suffering from fluid overload including: administrating a diuretic to the patient to increase urine output of the patient; monitoring intravascular volume of the patient; and maintaining the patient in a condition in which the intravascular volume is below a baseline intravascular volume and above a hemodynamic level by adjusting the administered diuretic.

Method and system to monitor urine output and manage fluid retention in a patient

Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

Neuromodulation cryotherapeutic devices and associated systems and methods

A apparatus and method to treat patients with acute decompensated heart failure (ADHF), heart failure or another fluid overload condition, that includes: administrating a diuretic to the patient to increase urine output of the patient; monitoring a rate or amount of urine output by the patient after administration of the diuretic; infusing a hydration liquid into the patient to induce an increase in the urine output; and adjusting the rate or amount of the hydration liquid infused into the patient to achieve a target fluid loss in the patient.

Method and system to treat acute decompensated heart failure

A method and apparatus for treatment of hypertension and heart failure by increasing secretion of endogenous atrial hormones by pacing of the heart. Pacing is done during the ventricular refractory period resulting in premature atrial contraction that does not result in ventricular contraction. Pacing results in the atrial wall stress, peripheral vasodilation, ANP secretion. Concomitant reduction of the heart rate is monitored and controlled as needed with backup pacing.

Methods and apparatus to stimulate the heart

A lead system and method of use for treating breathing disorders by the transvenous stimulation of the phrenic nerve.

Transvenous phrenic nerve stimulation system

Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.

Bilateral renal neuromodulation

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

Methods and apparatus for renal neuromodulation

Microwave catheter apparatuses, systems, and methods for renal neuromodulation

An ablation catheter configured to ablate tissue in a lung of a patient including: a flexible shaft that advances endobronchially into an airway of the lung and has an outer diameter of 2.0 mm or less; an ablation electrode attached to a distal portion of the flexible shaft and to deliver radiofrequency (RF) electrical current to the tissue and conductively connectable to an RF electrical energy source external to the patient; wherein an outer diameter of an assembly of the flexible shaft and the ablation electrode is no greater than 2.0 mm; a liquid outlet on the distal portion and configured to be in fluid communication with a source of hypertonic saline solution; and a first occluder attached to the flexible shaft proximal to the ablation electrode and proximal to the liquid outlet, wherein the first occluder is configured to expand to occlude the airway.

A method for treating a heart failure patient by ablating a nerve of the splanchnic sympathetic nervous system to increase venous capacitance and reduce pulmonary blood pressure. A method including: inserting a catheter into a vein adjacent the nerve, applying stimulation energy and observing hemodynamic effects, applying ablation energy and observing hemodynamic effects, applying simulation energy after the ablation and observing hemodynamic effects.

Devices and methods for treatment of heart failure by splanchnic nerve ablation

Systems, devices, and methods for transvascular ablation of target tissue are disclosed herein. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.

Methods and devices for endovascular ablation of a splanchnic nerve

Growing community of inventors

New York, NY, United States of America

Mark Gelfand