Hoechst Marion Roussel

Hoechst Roussel Pharmaceuticals

Aventis Pharmaceuticals Inc.

Novartis Ag

Mark G Palermo

Lawrence L Martin

Feng He

Raymond W Kosley, Jr

Gang Liu

Qian Zhao

Helen H Ong

Peter A Nemoto

Martin Sendzik

James Clifford Sutton

Zhuoliang Chen

Keith Bruce Pfister

Gerard J O'Malley

Cynthia Shafer

Lawrence Blas Perez

Troy Douglas Smith

Michael David Shultz

Fan Yang

Rajesh Karki

Christopher Sean Straub

Christine Hiu-Tung Chen

Jorge Garcia Fortanet

Julian Roy Levell

Bakary-Barry Toure

Michael C Merriman

Leigh Zawel

Stephen J Shimshock

Mark G Charest

Bing Yu

Abran Q Costales

Young Shin Cho

Yaping Wang

Sushil Kumar Sharma

Run-Ming David Wang

Wojciech Wrona

Francois Lenoir

Thomas Raymond Caferro

Patrick James Sarver

Yanlin Zhang

Veronica Wolf

Lucian V Dipietro

Andriana Jouk

Matthew J Lamarche

Huangshu Lei

Christopher Straub

Gerard J O'malley

Raymond W Kosley

Noel Chin Chin

Jianme Fan

Rung-Ming David Wang

Novel aminoalkylphenols, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction utilizing the aminoalkylphenols or compositions thereof are disclosed.

Aminoalkylphenol derivatives and related compounds

Novel spiro&lsqb;cyclopent&lsqb;b&rsqb;indole-piperidines&rsqb;, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the spiro&lsqb;cyclopent&lsqb;b&rsqb;indole-piperidines&rsqb; and intermediates, or compositions thereof are disclosed.

Spiro&lsqb;cyclopent&lsqb;b&rsqb;indole-piperidines&rsqb;

Novel spiro[cyclopent[b]indole-piperidines], intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the spiro[cyclopent[b]indole-piperidines] and intermediates, or compositions thereof are disclosed.

Spiro[cyclopent[b]indole-piperidines]

This application relates to compounds of the formula ##STR1## wherein R.sup.1,X, Y and n are as defined in the specification; and pharmaceutically acceptable addition salts thereof and optical and geometric isomers or racemic mixtures thereof; which compounds are useful for the treatment of various memory dysfunctions characterized by a decreased cholinergic function such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and hence are useful as antidepressants.

Substituted 3-(aminoalklamino)-1,2-benzisoxazoles and related compounds

This invention relates to compounds of the formula wherein X, Y, Z, m, n and p are as defined within, pharmaceutical compositions containing these compounds and to their use as antipsychotic agents, particularly in the treatment of schizophrenia. Depot derivatives of the compounds are useful for providing long acting effects of the compounds.

Antipsychotic agents, compositions and method of use

This invention relates to compounds of the formula ##STR1## wherein X, Y, Z, m, n and p are as defined within, pharmaceutical compositions containing these compounds and to their use as antipsychotic agents, particularly in the treatment of schizophrenia. Depot derivatives of the compounds are useful for providing long acting effects of the compounds.

This application relates to compounds of the formula ##STR1## wherein R.sup.1, X, Y and n are as defined in the specification; and pharmaceutically acceptable addition salts thereof and optical and geometric isomers or racemic mixtures thereof; which compounds are useful or the treatment of various memory dysfunctions characterized by a decreased cholinergic function such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and hence are useful as antidepressants.

Substituted 3-(aminoalkylamino)-1, 2-benzisoxazoles and related compounds

Antipsychotic agents, composition and method of use

Novel spiro�cyclopent�b!indole-piperidines!, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the spiro�cyclopent�b!indole-piperidines! and intermediates, or compositions thereof are disclosed.

Spiro�cyclopent�b!indole-piperidines!

This application relates to compounds of the formula ##STR1## wherein R.sup.1, X, Y and n are as defined in the specification; and pharmaceutically acceptable addition salts thereof and optical and geometric isomers or racemic mixtures thereof; which compounds are useful for the treatment of various memory dysfunctions characterized by a decreased cholinergic function such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and hence are useful as antidepressants.

Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds

There are disclosed various compounds of the formula below, ##STR1## where n, X and R.sub.1 through R.sub.4 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and/or act at central .alpha..sub.2 -adrenergic receptors, and hence are useful as antidepressants.

Substituted 1,2,3,4-tetrahydrocyclopent b!indoles, compositions and use

Growing community of inventors

Netcong, NJ, United States of America

Mark G Palermo