Georgia Tech Research Corporation

Cardiomems, Inc.

Ngimat Co.

University of Illinois

Icon Medical Corporation

St. Jude Medical Luxembourg Holdings Ii S.a.r.l. (“Sjm Lux Ii”)

St. Jude Medical Luxembourg Holdings Ii S.a.r.l.

St. Jude Medical Luxenbourg Holdings Ii S. A. R. L (“Sjm Lux Ii”)

Mark G Allen

Jason Kroh

Mark R Prausnitz

Michael Fonseca

Ari Glezer

Jason White

Florent Cros

Michael G Ellis

David O'Brien

David Stern

Jin Woo Park

Andrew Tye Hunt

Devin V McAllister

Donald J Miller

Martin A Brooke

Nan M Jokerst

Liang You

Inder-Jeet Gujral

James Joy

Wilton Pyle

Jin-Woo Park

William P Taylor

Chong-Hyuk Ahn

Charles C Chung

Yong-Kyu Yoon

James David Ross

Swaminathan Rajaraman

Sebastien Henry

Wayne J Book

Jaroslaw Rossignac

Christophe Courcimault

David W Rosen

Barton L Smith

John W Wiltse

Mark A Trautman

Jung-Hwan Park

Jae Y Park

Jennifer M English

David J Coe

Yeun-Ho Joung

David Kiesling

Florent Paul Marcel Cros

Imme Ebert-Uphoff

Donald E Ackley

Jay Yadav

Thomas R Jackson

Donald Lynn Miller

Emmanouil Tentzeris

Raghavendran Mahalingam

Edgar A Brown

Bruce C Wheeler

Yongdong Jiang

Stephen P DeWeerth

Todd A Polley

Robert E Schwerzel

Timothy J Drabik

Zhiyong Zhao

Scott Flanagan

Xiaosong Wu

Ioannis Papapolymerou

Fe Alma Gladden

Thierry C Leichle

Seong-O Choi

Jung-Hwan Pauk

Yanzhu Zhao

Yoonsu Choi

Bo Pan

Lora G Weiss

John Wegman

Matthew Scott Vinson

J Eric McEntyre

J Stevenson Kenney

Paul Floretn Cros

Yong Kyu Yoon

Kim Kieun

Jeong-Bong Lee

Sung-Pil Chang

David O'brien

Devin V Mcallister

Wireless sensors configured to sense, record and transmit data are provided herein. In one aspect, the wireless sensor has a power harvesting unit; a transducing A-to-D converter unit, a microcontroller unit, and a transmitting coil. The power harvesting unit is configured to receive an external energizing magnetic field generated by an external interrogator and store the energy generated thereby. The transducing A-to-D converter unit has a passive electrical transducer configured to respond to variations in a physical property and a converter configured to measure a characteristic value of the passive electrical transducer and provide a digital signal that is indicative of the measured characteristic value. The microcontroller unit is electrically coupled to the power harvesting unit and the transducing A-to-D converter unit and is configured to receive the digital signal from the transducing A-to-D converter unit. The transmitting coil is configured to receive the digital signal and to transmit the digital signal to the external interrogator. Upon receiving a start signal, the transducing A-to-D converter unit charges a current through the passive electrical transducer until a reference voltage is reached and, upon reaching the reference voltage, the microcontroller unit receives the digital signal.

Physical property sensor with active electronic circuit and wireless power and data transmission

Methods are provided for fabricating three-dimensional electrically conductive structures. Three-dimensional electrically conductive microstructures are also provided. The method may include providing a mold having at least one microdepression which defines a three-dimensional structure; filling the microdepression of the mold with at least one substrate material; molding the at least one substrate material to form a substrate; and depositing and patterning of at least one electrically conductive layer either during the molding process or subsequent to the molding process to form an electrically conductive structure. In one embodiment, the three-dimensional electrically conductive microstructure comprises an electrically functional microneedle array comprising two or more microneedles, each including a high aspect ratio, polymeric three dimensional substrate structure which is at least substantially coated by an electrically conductive layer.

Method for making electrically conductive three-dimensional structures

Provided herein are apparatus and methods relating to the development of instrumentation for high throughput network electrophysiology and cellular analysis. More specifically, provided herein are multiwell microelectrode arrays (MEAs) and methods for the development of such an apparatus in an inexpensive fashion with a flexible, ANSI/SBS-compliant (American National Standards Institute/Society for Biomolecular Screening) format. Microelectrode arrays are a grid of tightly spaced microelectrodes useful for stimulating and sensing electrically active cells, networks and tissue. The techniques described herein relate to the use of microfabrication in combination with certain large-area processes that have been employed to achieve multiwell MEAs in ANSI/SBS-compliant culture well formats, which are also transparent for inverted/backside microscopy compatibility. These multiwell MEAs can be used to investigate two and three-dimensional networks of electrically active cells and tissue such as cardiac, neural, and muscular in a high throughput fashion. Also being ANSI/SBS-compliant, they are compatible with machinery and robotics developed for the pharmaceutical industry for drug screening applications.

Apparatus and methods for high throughput network electrophysiology and cellular analysis

A wireless sensor for indicating a physical state within an environment includes a housing defining a hermetically sealed cavity. A structure located within the cavity of the housing has elements providing capacitance, the elements being arranged such that the distance and thereby the capacitance of the structure changes when a physical state of the environment changes. The structure has a resonant frequency based at least in part on the capacitance of the structure when in the presence of a fluctuating electromagnetic field. When the sensor is positioned within an environment and is subjected to a fluctuating electromagnetic field, the resonant frequency indicates the physical state of the environment.

Implantable wireless sensor

Wireless sensors configured to record and transmit data as well as sense and, optionally, actuate to monitor physical properties of an environment and, optionally, effect changes within that environment. In one aspect, the wireless sensor can have a power harvesting unit; a voltage regulation unit, a transducing oscillator unit, and a transmitting coil. The voltage regulation unit is electrically coupled to the power harvesting unit and is configured to actuate at a minimum voltage level. The transducing oscillator unit is electrically coupled to the voltage regulation unit and is configured to convert a sensed physical property into an electrical signal. Also, the transmitting coil is configured to receive the electrical signal and to transmit the electrical signal to an external antenna.

Marine vehicle systems and methods are disclosed. The marine vehicle can be buoyancy controlled, enabling efficient, extended use of the marine vehicle. Buoyancy actuation can enable roll, pitch, and yaw of the marine vehicle, as well as translation in any direction. One or more elastic bladders can be disposed on or in the marine vehicle. The bladders can be selectively inflated and deflated to control movement of the marine vehicle.

Marine vehicle systems and methods

Microneedle devices are provided for transport of molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver material into or across a biological barrier from chambers in connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.

Microneedle devices and methods of manufacture and use thereof

The present invention comprises methods and devices for thermal treatment of a barrier to increase the permeability of the barrier. One form of increasing the permeability of the barrier comprises forming micropores which may be used for administration of active agents across the barrier, or may be used for sampling or collecting fluids, or may be used for detecting, measuring or determining analytes, or may be used for monitoring of physiological or other conditions. Devices of the present invention may comprise microheaters that are activated by inductive or ohmic heating power supply components.

Methods and devices for thermal treatment

Simple microneedle devices for delivery of drugs across or into biological tissue are provided, which permit drug delivery at clinically relevant rates across or into skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. The devices include a substrate to which a plurality of hollow microneedles are attached or integrated, and at least one reservoir, containing the drug, selectably in communication with the microneedles, wherein the volume or amount of drug to be delivered can be selectively altered. The reservoir can be formed of a deformable, preferably elastic, material. The device typically includes a means, such as a plunger, for compressing the reservoir to drive the drug from the reservoir through the microneedles, In one embodiment, the reservoir is a syringe or pump connected to the substrate.

Microneedle drug delivery device

The present invention determines the resonant frequency of a sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. The system energizes the sensor with a low duty cycle, gated burst of RF energy having a predetermined frequency or set of frequencies and a predetermined amplitude. The energizing signal is coupled to the sensor via magnetic coupling and induces a current in the sensor which oscillates at the resonant frequency of the sensor. The system receives the ring down response of the sensor via magnetic coupling and determines the resonant frequency of the sensor, which is used to calculate the measured physical parameter. The system uses a pair of phase locked loops to adjust the phase and the frequency of the energizing signal.

Communicating with an implanted wireless sensor

Various apparatuses, arrangements, and methods are provided for creating various structures including microstructures. In one embodiment, a method for creating a microstructure is provided comprising packing a plurality of particles into a micromold, and then applying energy to the particles in the micromold. As a result of the application of energy, a microstructure is formed in the micromold out of the particles. Thereafter, the microstructure is removed from the micromold.

Particle based molding

An electromagnetically coupled hermetic chamber includes a body defining a hermetic chamber. A first conductive structure is disposed within the hermetic chamber, and a second conductive structure is attached to the body outside of the hermetic chamber. The first conductive structure is electromagnetically coupled to the second conductive structure without direct electrical paths connecting the first and second conductive structures. Thus the first conductive structure can be coupled to external electronics without the need for electrical feedthroughs or vias that could compromise the integrity of the hermetic chamber.

Sensor with electromagnetically coupled hermetic pressure reference

A pressure cavity is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Micromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from the ambient in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g. intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.

Hermetic chamber with electrical feedthroughs

Growing community of inventors

Atlanta, GA, United States of America

Mark G Allen