Smith + Nephew

Ucl Business Plc

Imperial Biotechnology Limited

Danisco (UK Ltd)

Creanova Universal Closures Limited

Mark F Smith

Mark Howard

James Baker

Vijay Chudasama

Stephen Caddick

Patrick Lewis Blott

Graham Smith

Stephen John Curran

Brian Mark Thomson

Denise Pawlett

Paul D Browning

Helene Anne Lecomte

Nicholas Charlton Fry

Anthony C Dagger

David F Farrar

Julian A Webb

David Houldridge

Selvarajah Sivshanker

Anna F MacFarlane

Christopher I Reed

Elisabeth Hutson

Rebecca Crallan

Sarah Freestone

Roy Trayhern

David Morsley

Gary Paul Dowthwaite

Charles William Archer

Elizabeth Finnie

Rodney Druitt

Brian Thomson

The present invention relates to the use of a compound containing a moiety of formula (I) as a reagent for linking a compound of formula R&#x2014;H which comprises a first functional moiety of formula Fto a second functional moiety of formula F wherein X, X', Y, R, Fand Fare as defined herein. The present invention also provides related processes and products. The present invention is useful for creating functional conjugate compounds, and specifically conjugates in which at least one of the constituent molecules carries a thiol group.

Reversible covalent linkage of functional molecules

The present disclosure relates to a tissue collection apparatus including a housing defining an inlet and an outlet and a tissue scaffold suitable for disposal within the housing, the tissue scaffold configured to be loaded with the tissue under the application of an aspiration force applied through the tissue collection apparatus.

Tissue harvesting

The present disclosure relates to a tissue collection apparatus. The tissue collection apparatus comprises a housing defining an inlet and an outlet, a first filter disposed within the housing, a second filter disposed within the housing, the second filter configured to isolate tissue particles of a desired size that pass through the first filter under the application of an aspiration force applied through the housing. A method of harvesting tissue is also disclosed.

An implant, artificial or semi-artificial at implantation, for repairing an articular cartilage and osteochondral defect site in a mammalian, such as a human. The implant having at least a first surface and a second surface. The first surface shaped for being press-fitted into the defect site to create an interface between the first surface and a bone-cartilage region of the defect site, and the second surface shaped for being press-fitted into the defect site to create an interface between the second surface and an articular cartilage region of the defect site. The implant being seeded, prior to implantation, with chondroprogenitor cells, including superficial zone chondroprogenitor cells.

Tissue implant

The present invention relates to scaffolds which can be used as medical devices for guided tissue regeneration and repair, in particular the invention is directed to a scaffold comprising fibers having a mean fiber diameter of between from about 1.2 to 4.0 microns, wherein the fibers comprise a glycolide. The invention further relates to the use of the scaffolds for the selective capture of cell populations for a cell source material.

Scaffold

A method for accelerated cheese ripening using a primary starter culture and an attenuated bacterial starter culture, the attenuated bacterial starter culture is treated with surface active agents.

Cheese ripening process

A method for cheese ripening using a primary starter culture and an attenuated starter culture, wherein the attenuated starter culture is treated with a surface active agent, such as SDS, which substantially kills all of the attenuated starter culture cells, but maintain their enzyme activity, and accelerate cheese ripening without compromising flavor.

Surgical dressing

An absorbent device which comprises an absorbent layer having an apertured contoured polymer film attached to a surface, wherein this surface is provided with a plurality of depressions which communicate directly with the apertures in the film. The device may be produced by separating the polymer film and a carrier material which have been formed into a laminate having impressed therein raised areas defining, for example, the strands of net and depressed areas such that upon separation the depressed areas of the film remain attached together with associated portions of the attached absorbent, to the carrier, leaving the raised areas attached to the remainder of the absorbent.

Absorbent devices and precursors therefor

Growing community of inventors

Sheering, United Kingdom

Mark F Smith