The University of North Carolina at Chapel Hill

Mark F Sistare

H Holden Thorp

Mary E Napier

Jinheung Kim

Carson R Loomis

Dean H Johnston

A method of detecting a nucleic acid (e.g., DNA, RNA) that contains at least one preselected base (e.g., adenine, guanine, 6-mercaptoguanine, 8-oxo-guanine, and 8-oxo-adenine) comprises (a) reacting the nucleic acid with a transition metal complex capable of oxidizing the preselected base in an oxidation-reduction reaction; (b) detecting the oxidation-reduction reaction; and (c) determining the presence or absence of the nucleic acid from the detected oxidation-reduction reaction at the preselected base. The method may be used in a variety of applications, including DNA sequencing, diagnostic assays, and quantitative analysis.

Microelectronic device for electrochemical detection of nucleic acid hybridization

Electrochemical detection of nucleic acid hybridization

Microelectronic device

Growing community of inventors

Chapel Hill, NC, United States of America

Mark F Sistare