University of Minnesota

Mark Ericson

Carrie Haskell-Luevano

Certain embodiments of the invention provide a cyclic compound of formula I: wherein: Pro is a residue of L-proline; Xis a residue of Arg or DArg; Xis a residue of Phe or DPhe; Xis a residue of Phe, DPhe or hPhe; Xis a residue of a natural or unnatural amino acid; Xis a residue of Ala, Asp, Glu, Lys, His, Phe, Ser, Leu or Gly; Xis a residue of Phe, Ala, Gly, Ser, Lys, Asp, Leu, Nle, Trp, Tyr, Cha or hPhe; and DPro is a residue of D-proline; or a salt thereof. Certain embodiments also provide compositions comprising such compounds, as well as methods of using such compounds and compositions.

Cyclic peptides and methods of use thereof

The invention provides compounds having the general formula I: and salts thereof, wherein the variables Pro, DPro, DPhe, Arg, Trp, X, X, Xand Xhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

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Minneapolis, MN, United States of America

Mark Ericson