Oriel Therapeutics, Inc.

Mark Ennis Ketner

Anthony James Hickey

Keith Johnson

Bruce S Ferris

Jeffrey Alan Warden

William Myles Riley

Timothy M Crowder

Jay Kinsley Fording

Michael Duane Garten

Sean Anderson

Paul Gilbert Rockwell

Dry powder inhalers with a multi-dose dry powder package for dispensing pharmaceutical grade formulations of inhalable dry powder, include: (a) a blister package comprising a plurality of spaced apart sealed blisters thereon, each blister having a projecting ceiling and a floor defining a blister channel therebetween, the blister channel comprising a dry powder therein; (b) a movable blade cartridge holding a blade at a forward portion thereof; and (c) an extendable mouthpiece attached to the movable blade cartridge. In operation, a user pulls the mouthpiece outward and then pushes the mouthpiece inward to cause the blister package to advance to position a blister in a selected dispensing position in the inhaler and to cause the blade cartridge to move the blade across a blister ceiling held in the dispensing position in the inhaler to thereby open the blister held in the dispensing position.

Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances

Dry powder blister packages include sealed blisters with a piezoelectric active layer that flexes to vibrate the dry powder in a blister to facilitate active dispersion.

Blister packages with frames and associated methods of fabricating dry powder drug containment systems

Growing community of inventors

Apex, NC, United States of America

Mark Ennis Ketner