Jazz Pharmaceuticals Ireland Limited

Jazz Pharmaceuticals, Inc.

Mark Eller

Clark Patrick Allphin

Katayoun Zomorodi

Gunjan H Junnarkar

Cuiping Chen

Roman Skowronski

One embodiment of the present invention is to improve the safety and efficacy of the administration of GHB or a salt thereof to a patient. It has been discovered that the concomitant administration of an MCT inhibitor, such as diclofenac, valproate, or ibuprofen, will affect GHB administration. For example, it has been discovered that diclofenac lowers the effect of GHB in the body, thereby potentially causing an unsafe condition. Furthermore, it has been discovered that valproate increases the effect of GHB on the body, thereby potentially causing an unsafe condition.

Method of administration of gamma hydroxybutyrate with monocarboxylate transporters

Provided herein are pharmaceutical compositions and formulations comprising mixed salts of gamma-hydroxybutyrate (GHB). Also provided herein are methods of making the pharmaceutical compositions and formulations, and methods of their use for the treatment of sleep disorders such as apnea, sleep time disturbances, narcolepsy, cataplexy, sleep paralysis, hypnagogic hallucination, sleep arousal, insomnia, and nocturnal myoclonus.

Gamma-hydroxybutyrate compositions and their use for the treatment of disorders

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Redwood City, CA, United States of America

Mark Eller