Pioneer Hi-bred International, Inc.

E.i. Dupont De Nemours and Company

Mark Edward Nelson

Albert Laurence Lu

Michael W Lassner

James Kevin Presnail

Lu Liu

Rafael Herrmann

Janet Ann Rice

Takashi Yamamoto

Ruth Cong

Jingtong Hou

Gusui Wu

John P Mathis

James M Hasler

Deirdre M Kapka-Kitzman

Catherine J Clark

Naga Kishore Kakani

Song Leng

Claire Marie Bazyk

Nuria Jimenez-juarez

The disclosure relates to insecticidal toxin resistance management and screening of novel insecticidal toxins. One embodiment relates to the isolation, characterization, compositions, and methods of use relating to polynucleotides encoding novel insecticidal toxin receptors and the polypeptides encoded thereby. The polynucleotides and polypeptides are useful in identifying or designing novel insecticidal toxin receptor ligands including novel insecticidal toxins.

Insecticidal toxin receptors and methods of use

Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.

Compositions and methods for the suppression of target polynucleotides from lepidoptera

Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from thegenus, is capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides from specific polypeptide families as disclosed herein, or active variants thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest. Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. Plants, plant parts, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.

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Newark, DE, United States of America

Mark Edward Nelson