University System of Maryland

The United States Government As Represented by the Department of Veterans Affairs

Northern Arizona University

Arizona State University

Mark E Shirtliff

Jeffrey Leid

Paul E Bigeleisen

Jeffrey G Leid

Cha-Min Tang

Timothy L Vail

Jennifer M Kofonow

Janette Harro

Samuel M Galvagno, Jr

Rebecca A Brady

Graeme O'May

Jeff Leid

Kyle Kenney

Jennifer A Kofonow

Graeme O' May

A thermo-responsive ultrasound coupling gel that contains a thermo-responsive polymer such as poly(n-isopropyl acrylamide), the gel having a phase shift at a temperature in the range of 32 to 35° C. such that the gel has a loss factor G″/G' of >1 at <32° C. and a loss factor G″/G′ of <1 at >35° C. The gel can also contain at least one of a solvent and gelling agent. Methods and uses for the thermo-responsive ultrasound coupling gel in an ultrasound and/or ultrasound guided procedure.

Thermo-responsive ultrasound coupling gel, and methods and uses thereof

A device disclosed herein includes a tubular member which is flexible and configured to receive ultraviolet (UV) light from a UV illumination coupler. The tubular member contains a lumen defining a longitudinal interior space within the tubular member, a tubular body bounded by an inner wall defining an outer boundary of the lumen and an outer wall defining an outer surface of the tubular member, at least one optical fiber disposed outside of the interior space not parallel to an axis of the lumen and adapted to receive the UV light from the UV illumination coupler, and a protective component adapted to prevent substantively all of the UV light emitted from the optical fiber from exiting the outer wall. Methods for producing and using such devices are also disclosed herein.

Ultraviolet sterilizing drainage catheter

Vaccine formulations effective against Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA) are disclosed, as well as methods of using the vaccine formulations in the treatment and prevention of Staphylococcus aureus infections in a subject.

Multivalent vaccine protection frominfection

Ultraviolet Sterilizing Drainage Catheter

Vaccine formulations effective against, including methicillin-resistant(MRSA) are disclosed, as well as methods of using the vaccine formulations in the treatment and prevention ofinfections in a subject.

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The present invention relates to a method for in vivo detection of a biofilm infection residing in a mammal, the method comprising (i) administering to the mammal a diagnostic-effective amount of a biofilm-specific probe, wherein the probe comprises a bio film-targeting moiety and a paramagnetic nanoparticle core; and (ii) imaging the mammal to detect the presence of the biofilm infection by observing the mammal using a magnetic resonance diagnostic technique after the biofilm-specific probe has been provided sufficient time to selectively bind to the bio film infection that may be present in the mammal. The invention also relates to methods of treatment of a bio film infection, and compositions and kits useful in the detection and/or treatment of bio film infections.

In vivo biofilm infection diagnosis and treatment

The present invention provides methods and kits for biofilm detection.

Methods and devices for the detection of biofilm

Vaccine formulations effective against, including methicillin-resistant(MRSA) are disclosed, as well as methods of using the vaccine formulations in the treatment, prevention and prophylaxis ofinfections in a subject.

Growing community of inventors

Ellicott City, MD, United States of America

Mark E Shirtliff