Warner-lambert Company

Mark E Marlatt

Vladimir Genukh Beylin

Om Prakash Goel

John G Topliss

Huai G Chen

Richard Jungkyu Lee

The present invention relates to a process for preparing 2-(pyridin-4-ylamino-pyrido [2,3-d]pyrimidine of Formula IIby reacting a 4-aminopyridine of the formulawith a 2-(4-imino-4H-pyridin-1-yl)-pyrido[2,3-d]pyrimidine of Formula Iin the presence of a base. It also relates to an alternative process for preparing a compound of Formula II by reacting the aminopyridine hereinabove within a unreactive organic solvent. It also relates to the compound of Formula III.

Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido[2,3-d]pyrimidin-7-ones

Novel cyclic amino acids which are useful in preparing biologically active peptides as well as a process for the preparation of D and L enantiomers of the cyclic amino acids are described where an N-protected derivative of the racemic cyclic amino acid is treated with (-)cinchonidine and the resulting salt resolved into the desired enantiomers, as well as derivatives thereof and valuable intermediates used in the process.

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Grass Lake, MI, United States of America

Mark E Marlatt