University of Rochester

Georgetown University

Mark E Mapstone

Howard J Federoff

Massimo S Fiandaca

Amrita K Cheema

Xiaogang Zhong

Charles Joseph Duffy

Yuriy Gusev

Laura Cushman

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.

Metabolic biomarkers for memory loss

The present invention relates to methods of determining if a subject has a decreased risk of suffering from future memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has a decreased risk of suffering from future memory impairment compared to a normal individual.

Metabolic biomarkers for cognitive ability

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's proteomic profile and comparing the value of the subject's proteomic profile with the value of a normal proteomic profile. A change in the value of the subject's proteomic profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.

Protein biomarkers for memory loss

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing the gene expression profile from peripheral blood leukocytes taken from the subject and comparing the value of the subject's gene expression profile with the value of a normal gene expression profile. A change in the value of the subject's gene expression profile, above or below normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.

Genetic markers for memory loss

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's lipidomic profile, and comparing the value of the subject's lipidomic profile with the value of a normal lipidomic profile. A decrease in the value of the subject's lipidomic profile over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.

Biomarkers for memory loss

A method for assessing the navigational capacity in human subjects, and its use in diagnosing spatial disorientation in neurodegenerative diseases, such as, for example Alzheimer's disease. The method for assessing the navigational capacity includes conducting a spatial orientation test, recording the results of the test, analyzing the test results and making a determination of the navigational capacity of a human subject. In its most simple sense, navigational capacity includes the capacity not to get lost. The spatial orientation test includes various naturalistic navigation tasks that are each designed to assess specific areas of the navigational capacity of a subject.

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Pittsford, NY, United States of America

Mark E Mapstone