Beth Israel Deaconess Medical Center, Inc.

Johns Hopkins University

Oregon Health & Science University

Mark E Josephson

Alexei V Shvilkin

Larisa G Tereshchenko

A method and system for determining a patient's risk of ventricular tachycardia are disclosed. The method includes receiving ECG signals from a patient and filtering the collected ECG signals to generate filtered ECG signals. The method further includes identifying a heart vector from the filtered ECG signals, and measuring a velocity of the heart vector movement. A change in curvature of the identified heart vector movement is quantified and a risk of ventricular tachycardia is determined based at least on the measured velocity and the quantified change in curvature of the identified heart vector movement.

Method and system to access inapparent conduction abnormalities to identify risk of ventricular tachycardia

A method of discriminating between ischemic and cardiac memory effects in a heart, comprising receiving electrocardiographic (ECG) data, calculating, from the ECG data, a direction of a T-wave vector, diagnosing ischemia if the T-wave vector is between about 75 degrees and about 200 degrees, and diagnosing cardiac memory if the T-wave vector is between about zero degrees and minus 90 degrees. Also presented is a system for discriminating between ischemic and cardiac memory effects in a heart comprising means for performing an electrocardiogram, means for calculating a direction of a T-wave vector, means for diagnosing ischemia if the T-wave vector is between about 90 degrees and 180 degrees, and means for diagnosing cardiac memory if the T-wave vector is between about zero degrees and minus 90 degrees.

Differentiating ischemic from non-ischemic T-wave inversion

A method of differentiating between ischemic and cardiac memory inverted T-waves includes performing an electrocardiogram of a patient; identifying inverted T-waves in at least some of precordial leads; identifying T-waves in leads I and aVL; diagnosing ischemia if leads I and aVL show inverted T-waves; and diagnosing cardiac memory if the leads I and aVL show non-inverted T-waves. The method may also include identifying T-waves in lead III; confirming ischemic diagnosis if the lead III shows deeper inverted T-waves than in the precordial leads; and confirming cardiac memory diagnosis otherwise.

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Brookline, MA, United States of America

Mark E Josephson