Ligand Pharmaceuticals, Inc.

Merck + Co., Inc.

Signal Pharmaceuticals, Inc.

Mark E Goldman

Todd Kevin Jones

Lin Zhi

David T Winn

James Patrick Edwards

Christopher Michael Tegley

Lawrence G Hamann

Luc J Farmer

Sarah J West

Robert L Davis

Charlotte Lf Pooley

William J Greenlee

Clarence S Rooney

Theresa M Williams

Walfred S Saari

William C Lumma, Jr

John S Wai

Mark J Suto

Philip E Sanderson

Joel R Huff

Terrence M Ciccarone

Jacob M Hoffman, Jr

Suresh K Balani

Moorthy S Palanki

Leah M Gayo

Robert Warren Sullivan

Lynn J Ransone-Fong

Michael G Johnson

Charlotte L F Pooley

Anthony D Theoharides, Deceased

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.

Steroid receptor modulator compounds and methods

Process for preparing steroid receptor modulator compounds

Compounds having utility as antinflammatory agents in general and, more specifically, for the prevention and/or treatment of immunoinflammatory and autoimmune diseases are disclosed. The compounds are pyrimidine- or pyrazine-containing compounds and, in one embodiment, are carboxyamides of the same. Methods are also disclosed for preventing and/or treating inflammatory conditions by administering to an animal in need thereof an effective amount of a compound of this invention, preferably in the form of a pharmaceutical composition.

Pyrimidine carboxamides and related compounds and methods for treating

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiting steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.

Tricyclic steroid receptor modulator compounds and methods

Non-steroidal compounds which are high affinity, high specificity ligand antagonists for the androgen receptor are disclosed. Also disclosed are methods for employing the disclosed compounds for modulating processes mediated by the androgen receptor and for treating patients requiring androgen receptor antagonist therapy.

Non-steroid androgen receptor antagonist compounds and methods

Novel indole compounds inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

Inhibitors of HIV reverse transcriptase

Growing community of inventors

San Diego, CA, United States of America

Mark E Goldman