Bio Med Sciences, Inc.

Tetratec Corporation

Mark E Dillon

Joseph E Dillon

Joseph A Dillon

Richard Brandimarte

Raymond E Triglia

Sean Michael Adams

Krishna Narayanan

A wound dressing for active continuous debridement of devitalized tissues in non-healing wounds including diabetic ulcers, pressure ulcers, burn injuries and other etiologies, includes an active ingredient, such as collagenase, which serves to debride wounds in-situ. In one example, purified Collagenase (90% pure) was deposited onto several wound dressing materials. A key feature of this invention is that the activity level of the Collagenase used was substantially preserved.

Debriding wound dressing, process of manufacture and useful articles thereof

This invention relates to a novel method of reducing the appearance of rhytides ('facial wrinkles') and/or infra-orbital shadows ('dark circles') under the eyes, and striae (&#x201c;stretch marks&#x201d;), or lentigo senilis (&#x201c;age spots&#x201d;), and hyper/hypo pigmentation on other anatomical areas. Particularly, this invention relates to a topical patch worn on the skin that in a preferred embodiment incorporates two distinct layers, each providing useful features and together providing a novel article and method of improving skin cosmesis. Ease of use, patient comfort and cost effectiveness are provided. The patch is applied to the affected area and preferably worn at least several hours and more preferably worn overnight. The product increases the hydration level of the skin over which it is applied. There is a slight increase to the volume of the local superficial tissue, which serves to tighten the overlying skin and reduce the size and quantity of fine wrinkles at least temporarily. Various active ingredients, such as peptides, vitamin compounds, antioxidants, growth factors, glycolic or alphahydroxy acids, etc., may be incorporated into the present invention thereby providing an enhanced effect or other perceived advantage in the market.

Wrinkle reducing skin patch, process of manufacture and useful articles thereof

Therapeutic medical garments for scar treatment includes a composite fabric for treating dermatological scars, wherein a layer of textile fabric and a layer of a therapeutic agent produce a composite sheet suitable for the treatment of dermatologic scars resulting from traumatic, surgical or other injuries to the skin. The composite sheet may be fashioned into garments fitted to the patient for convenience of use, optimization of skin contact, and single step application of pressure therapy and the therapeutic agent. A process of use of the medical garment for applying therapeutic agent and pressure therapies.

Therapeutic medical garments with silicone sheeting component for scar treatment, process of manufacture and use

A novel method of producing interpenetrating polymer network ('IPN') sheeting. Particularly, an improved method of producing such sheeting and bonding it to a backing layer for use as various types of wound dressings and scar management products. The new process represents several improvements over previous techniques as follows: a) single-pass process, b) no second coating of liquid polymer required to act as glue, c) no solvents or other processing aids required, d) no additional oven length needed to effect the required dwell time, e) increased line speed relative to prior techniques, and g) the carrier substrateneed only be coated with a release surface on one side.

Process for the manufacture of interpenetrating polymer network sheeting and useful articles thereof

A microporous membrane is described comprising at least two layers, wherein each layer is characterized by nodes interconnected by fibrils, the layers are bonded by means of plastic flow at temperatures below the melting point of either membrane material, and the pore architecture is formed in situ by an expansion process. A stratified microporous membrane is produced wherein the pore architecture of each layer may be discretely controlled. The article is useful for filtration and medical applications where a pore size gradient is required.

Microporous membrane with a stratified pore structure created in situ and process

Elastomeric sheeting materials are described which are formed from the process of (1) creating a membrane comprising a semi-interpenetrating polymer network ('IPN') of polytetrafluoroethylene ('PTFE') and polydimethylsiloxane ('PDMS') by causing a matrix of PDMS to be formed in situ with a matrix of PTFE; (2) causing a surface of substantially pure PDMS to be formed on at least one side thereof; (3) allowing said PDMS compositions to vulcanize; and (4) converting said structure into useful shapes suitable for application to anatomical areas of the body. The product of the process is suitable for the treatment of dermatologic scars, such as those associated with traumatic or surgical injuries of the skin. The pure PDMS layer provides desired therapeutic effects. The semi-IPN membrane provides improved physical integrity, durability, and elastic behavior in comparison to prior art. The combined structure has increased compliancy, a thinner profile, and improved patient comfort features in comparison to existing products.

Semi-interpenetrating polymer network scar treatment sheeting, process

A thermoplastic splinting material with a uniform skin contacting layer of silicone elastomer which accurately contours complex anatomical geometries and is suitable for use in the treatment of dermatologic scars. The product is manufactured in sheet form and may be custom shaped to fit the unique contours of an individual patient by a technician at the clinical site.

Silicone thermoplastic sheeting for scar treatment and useful article

Microporous waterproof and moisture vapor permeable products are described which are formed from a matrix having an internal microstructure which is coated with a hydrophobic material. A process is described including the steps of (1) applying to the surface of the matrix a liquid hydrophobic material, (2) allowing the liquid to penetrate into the microstructure and then (3) drying, vulcanizing or curing the product.

Microporous waterproof and moisture vapor permeable fabric

Microporous waterproof and moisture vapor permeable structures,

A process for producing a semi-interpenetrating polymer network of polytetrafluoroethylene and silicone elastomers is described which comprises the steps of (1) intimately blending a mixture of a major amount of unsintered and unfibrillated particulate polytetrafluoroethylene dispersion resin and minor amounts of (A) a hydrocarbon liquid and (B) an addition curable silicone composition consisting essentially of a polydiorganosiloxane having alkenyl unsaturation, an organohydrogenpoly-siloxane crosslinking agent, a catalyst for promoting crosslinking of said polysiloxane, and an inhibitor for the catalytic reaction; (2) forming said blend into an extrudable shape; (3) biaxially extruding said blend through a die into a shaped extrudate product having a randomly fibrillated structure; (4) evaporating said hydrocarbon liquid, and activating said catalyst so as to generate a cured silicone elastomer and polytetrafluoroethylene semi-interpenetrating polymer network comprising said fibrillated extrudate structure. Products produced by this process have improved physical properties as compared to extruded fibrillated polytetrafluoroethylene dispersion resin alone.

Process of producing a fibrillated semi-interpenetrating polymer network

A composite self-supporting flexible agglomerated macrostructure is described which includes (1) a matrix of unfibrillated polytetrafluoroethylene resin and addition curable silicone and (2) particulate material including hydroxyapatite and/or tricalcium phosphate uniformly distributed throughout said matrix, the macrostructure being uniformly permeated by a network of open pores formed in the process of manufacture by intimately blending particulate sodium chloride and subsequently leaching the sodium chloride particles.

Process of producing a composite macrostructure of organic and inorganic

A composite self-supporting flexible agglomerated macrostructure is described which comprises (1) a matrix of unfibrillated polytetrafluoroethylene resin and addition curable silicone and (2) particulate material including hydroxyapatite and/or tricalcium phosphate uniformly distributed throughout said matrix, the macrostructure being uniformly permeated by a network of open pores formed in the process of manufacture by intimately blending particulate sodium chloride and subsequently leaching the sodium chloride particles.

Composite macrostructure of ceramic and organic biomaterials

An improved bandage comprises a backing sheet constructed of a semi-interpenetrating polymer network. Use of a semi-interpenetrating polymer network allows for an extremely desirable combination of gas permeability and hydrostatic resistance. This construction of backing sheet provides for suitable vapor permeability and sufficient water impermeability because the pores therein are of a colloidal size range and the surface tension thereof results in the backing material being hydrophobic.

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Allentown, PA, United States of America

Mark E Dillon