Medtronic Ardian Luxembourg S.a.r.l.

The Foundry, Inc.

Twelve, Inc.

Mati Therapeutics Inc.

Pivot Medical, Inc.

Ardian, Inc.

Medtronic, Inc.

Cotera, Inc.

Other

Stryker Corporation

Devices for Vascular Intervention, Inc.

Qlt Inc.

Nuvaira, Inc.

Holaira, Inc.

Foundry Therapeutics, Inc.

Mark E Deem

Hanson Gifford

Hanson S Gifford, Iii

Mark Gelfand

Howard R Levin

Denise Marie Zarins

Douglas Sutton

Vivek Shenoy

Nicolas Zadno

Benjamin J Clark

Stephen A Boyd

Darin Charles Gittings

Denise M Demarais

Cary J Reich

Eugene De Juan, Jr

John H Morriss

Andrew H Wu

Michael J Hendricksen

Doug Sutton

Michael Luna

Alan R Rapacki

Matt McLean

James I Fann

Jeffry J Grainger

James Flom

Bernard H Andreas

Douglas S Sutton

Kenneth J Michlitsch

Jean-Pierre Dueri

Thomas Weisel

Erik Thai

Martin L Mayse

Mark Y Hirotsuka

Sunmi Chew

Kent D Dell

J Brook Burley

William Kaiser

Steven Charles Dimmer

Ferolyn T Powell

Karun D Naga

John Streeter

David Boudreault

Hanson S Gifford

Lynette Ross

Matthew Frushell

Geoff Willis

Dwayne Dupree

Ron French

Matt Mclean

Andrew L Chiang

Paritosh Ambekar

Daniel J Conley

Cary Reich

Jeffrey J Grainger

Eugene De Juan

Honglei Wang

Koon Kiat Teu

Jingnan Luo

Grace Y Schulz

Daniel Boon Lim Seet

Wei Li Lee

Stephen W Boyd

Gerri L Chatelain

Ryan Kaveckis

Timothy Wayne Malisch

Darrin Gittings

Denise Demarals

Hanson G Gifford, Iii

James L Fann

Hanson Iii Gifford

Denise Demarais

Alan Rapacki

Iii Gifford Hanson

John Morriss

Hanson S Iii Gifford

Edward Harshmann

Devices and methods are disclosed herein for accessing the hip joint. A first device can be securely attached to the capsule of a joint. The first device can tent the capsule to increase the volume of the peripheral compartment. A second device can be biased against the first device to pierce the tented capsule and create a portal. Devices and methods are also disclosed herein for distending the capsule of a joint. A distention device may access a portal established within the capsule. The distention device can expand the capsule by applying an expansive force within the peripheral compartment. The distention device can maintain distention of the peripheral compartment while other devices access the joint.

Methods and devices for accessing and retracting a capsule of a joint

The devices, systems, and methods disclosed herein may be directed to a delivery system including a therapeutic member configured for endoluminal placement via the delivery system into the esophagus of the patient, wherein the therapeutic member comprises a treatment portion comprising a film for controlled release of a chemotherapeutic agent. The film may comprise a control region, a therapeutic region, and a substantially impermeable base region. The film is configured to release the chemotherapeutic agent in a direction away from the substantially impermeable base region. The delivery system is configured to enable a treatment provider to position the treatment portion of the therapeutic member proximate to a treatment site associated with the esophagus of the patient, and the therapeutic member is configured to administer a therapeutically effective dose to the treatment site for a sustained period following endoluminal placement of the therapeutic member.

Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents

An implant for insertion through a punctum and into a canalicular lumen of a patient. The implant includes a matrix of material, a therapeutic agent dispersed in the matrix of material, a sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen and to allow the therapeutic agent to be released from a surface of the matrix of material to a tear film, and a retention structure configured to retain the implant within the canalicular lumen.

Nasolacrimal drainage system implants for drug therapy

Systems, apparatuses, and methods for treating native heart valves are disclosed herein. A system for delivering a prosthetic device into a heart of a patient includes an elongated catheter body and a delivery capsule. The delivery capsule can be hydraulically driven to deploy at least a portion of a prosthetic heart valve device. The delivery capsule can release the prosthetic heart valve device at a desired treatment site in a patient.

Hydraulic delivery systems for prosthetic heart valve devices and associated methods

Pathologies of joints arising from improper force distributions are addressed by displacement of targeted connective and muscle tissues surrounding the joint in order to realign force vectors and alter moment arms loading the joint.

Method and apparatus for force redistribution in articular joints

Prostheses and methods for treating canine cruciate ligament disease are disclosed comprising placement of a specifically configured implant on the femur or tibia to displace targeted muscle or connective tissue associated with the stifle joint so as to reduce cranial tibial thrust.

Method and apparatus for treating canine cruciate ligament disease

An implant for insertion into a punctum of a patient comprises a body. The body has a distal end, a proximal end, and an axis therebetween. The distal end of the body is insertable distally through the punctum into the canalicular lumen. The body comprises a therapeutic agent included within an agent matrix drug core. Exposure of the agent matrix to the tear fluid effects an effective therapeutic agent release into the tear fluid over a sustained period. The body has a sheath disposed over the agent matrix to inhibit release of the agent away from the proximal end. The body also has an outer surface configured to engage luminal wall tissues so as to inhibit expulsion when disposed therein. In specific embodiments, the agent matrix comprises a non-bioabsorbable polymer, for example silicone in a non-homogenous mixture with the agent.

Drug delivery methods, structures, and compositions for nasolacrimal system

A method of treating a patient's joint having opposing joint surfaces includes providing an elongate member having a proximal end, a distal end and an expandable member near the distal end. The expandable member is positioned in the joint between the joint surfaces and expanded so as to separate the joint surfaces away from one another into a distracted position. The joint is manipulated while in the distracted position so that the joint is distracted and in flexion. A diagnostic or therapeutic procedure is then performed on the joint while maintaining the joint in the flexed and distracted position.

Methods and apparatus for joint distraction

A method for impacting a suture anchor into bone comprises providing an implantable suture anchor and providing an impactor device for impacting the suture anchor into the bone. The suture anchor is coupled to a distal portion of the impactor device. Positioning the suture anchor engages the anchor with the bone at an implantation site, and powering the impactor device impacts the suture anchor thereby implanting the suture anchor into the bone. The frequency of impaction is less than 20 KHz. The impactor device is then decoupled from the suture anchor, and the impactor device may be removed from the implantation site.

Methods and devices for suture anchor delivery

Various devices, systems and methods for knotless suturing of tissue are disclosed. These devices allow sutures to be anchored to bone, and more specifically provide a suture anchor which eliminates the need for knotting the suture. Thus, damaged tissue may be re-attached to a substrate tissue. The anchors have a minimum of moving parts may be suited to being a single molded polymer construction. The anchors will find particular utility in hip and shoulder arthroscopy, e.g. labral re-attachment and similar procedures.

Knotless suture anchor and methods of use

Prosthetic heart valve devices for percutaneous replacement of native heart valves and associated systems and method are disclosed herein. A prosthetic heart valve device configured in accordance with a particular embodiment of the present technology can include an anchoring member having a first portion configured to engage with tissue on or near the annulus of the native heart valve and to deform in a non-circular shape to conform to the tissue. The device can also include a valve support coupled to a second portion of the anchoring member, configured to support a prosthetic valve and having a cross-sectional shape. In some embodiments, the first portion of the anchoring member is mechanically isolated from the valve support such that the cross-sectional shape of the valve support remains sufficiently stable that the prosthetic valve remains competent when the anchoring member is deformed in the non-circular shape.

Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods

Pathology of the human spine can arise from excessive and/or uneven loading of regions within the spinal vertebrae and the intervertebral disc. Methods and apparatus are disclosed that enable displacement of soft tissue around the spine in a less invasive manner, thereby altering the mechanical load distribution within the spine to achieve a therapeutic effect.

Method and apparatus for altering biomechanics of the spine

Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.

Methods and apparatus for bilateral renal neuromodulation

Growing community of inventors

San Francisco, CA, United States of America

Mark E Deem