American Home Products Corporation

Mark E Coons

Gerald L Reuter

Chien-Chin Wu

Maureen M Harrison

Novel topical anesthetic compositions containing high concentrations of benzocaine in a micronized powder form suspended in an emollient vehicle.

Anesthetic compositions

An rehydratable antacid composition of magaldrate gel and a process for preparing same are described by the invention. The composition is prepared from and contains precipitated and undried magaldrate gel, a polyhydric alcohol and fluidizing amounts of a first and second fluidizer. One fluidizer is provided by an aluminum hydroxide gel having colloidal properties and the second by a pharmaceutically acceptable citrate ion source including citric acid. The process and composition are characterized in providing rehydratable antacid composition which when admixed with water forms a fluid, resuspendible, pharmaceutically elegant suspension possessing high antacid capacity and stability at even elevated magaldrate concentrations in addition to the ability to fluidize stiff, paste-like magaldrate gel cakes.

Rehydratable antacid composition

Therapeutic liquid oral dosage formulations of propranolol hydrochloride are provided which contain lecithin and/or a basic amino acid to impart taste masking characteristics and/or contain a basic amino acid to impart anesthesia masking characteristics.

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Champlain, NY, United States of America

Mark E Coons