University of Ottawa

Ottawa Hospital Research Institute

Mark Dornan

Jean-Simon Diallo

Fabrice Le Boeuf

Christopher Noyce Boddy

Rozanne Arulanandam

Ramya Krishnan

Jeffrey Smith

Andrew Macklin

Provided are compounds of Formula III that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.

Compositions and methods for viral sensitization

Provided are compounds of Formula (II) that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided. 

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Ottawa, Canada

Mark Dornan