Farmarc Nederland Bv

South African Druggists Limited

Mark David Bodley

Lawrence John Penkler

Michiel Coenraad Van Oudtshoorn

Lueta Ann Glintenkamp

Mino Rodolfo Caira

Douglas George Nicholson

Vivienne Jean Griffith

Luigi Renzo Nassimbeni

A method of preparing an injectable pharmaceutical or veterinary composition which comprises either diclofenac or a salt thereof and 2-hydroxypropyl beta-cyclodextrin, or an inclusion complex of diclofenac or a salt thereof and 2-hydroxypropyl beta-cyclodextrin, includes the step of dissolving either the diclofenac or salt thereof and the 2-hydroxypropyl beta-cyclodextrin, or the inclusion complex, in water to form a solution, the water having been acidified to a pH such that the pH of the solution is from 6.0 to 8.5 inclusive, in the absence of a phosphate buffer. The composition so produced has good stability on storage.

Pharmaceutical composition comprising diclofenac and cyclodextrin

An inclusion complex of diclofenac, preferably as diclofenac sodium, and an unsubstituted beta-cyclodextrin has the formula 1 molecule of diclofenac to 1 molecule of the unsubstituted beta-cyclodextrin and preferably from 5 to 11 water molecules. The inclusion complex may be formulated as a pharmaceutical composition.

Inclusion complex of beta-cyclodextrin and diclofenac, its preparation

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Charlo, South Africa

Mark David Bodley