Basf Corporation

Lumigen, Inc.

Abbott Laboratories Corporation

Mark D Sandison

Hashem Akhavan-Tafti

Richard S Handley

Lawrence E James

Randall K Larkin

Robert Gault

William H Harclerode

Klemens Massonne

Renuka De Silva

Gerd Konrad

Ron Eva

Gregory E Moffitt

John Banger

Wenhua Xie

Methods of producing fluorescence from fluorogenic substrates reactive with a peroxidase enzyme are disclosed. Use of the methods in assays for peroxidase enzymes, peroxidase-labeled analytes are provided. Fluorogenic compounds, compositions and kits for reaction with peroxidase enzymes are described. Two modes of producing fluorescent compounds are described.

Fluorescent detection of peroxidase enzymes

Improved polymer-immobilized photosensitizer are disclosed as well as methods of preparing and using them. The polymer-immobilized photosensitizers comprise a cross-linked polymer backbone, a plurality of cationic ammonium or phosphonium groups covalently bound to the polymer backbone and an immobilized photosensitizer. The average total number of carbon atoms in the ammonium or phosphonium group is at least four and preferably at least 12. The photosensitizer can be either covalently or ionically bound to the polymer. Polymer-supported photosensitizers of the invention are unexpectedly superior in catalyzing the photosensitized oxidation of compounds containing carbon-carbon double bonds.

Uses of improved polymer-supported photosensitizers in the generation of singlet oxygen

A method for the preparation of a ketone from a narcotic alkaloid having an allyl alcohol moiety is disclosed. The method includes mixing the narcotic alkaloid with an acid in the presence of a catalyst wherein the method is carried out in the substantial absence of hydrogen gas. The method is useful for preparing hydromorphone and hydrocodone compositions having novel impurity profiles. Compositions comprising hydromorphone and hydrocodone are also disclosed.

Hydromorphone and hydrocodone compositions and methods for their synthesis

Polymer-supported photosensitizers

Aqueous solutions of N-methylmorpholine N-oxide having reduced nitrosamine concentrations are produced by adding catalytic amounts of inorganic carbonate or bicarbonate or carboxylic acid or carboxylate salt.

Method for reducing the nitrosamine content of N-methylmorpholine-N-oxide

Aqueous solutions of N-methylmorpholine N-oxide having color numbers below 200 APHA, based on an N-methylmorpholine N-oxide content of 50% by weight, are produced by reacting aqueous hydrogen peroxide solutions with aqueous solutions of N-methylmorpholine having a water content of at least 35% by weight.

Production of almost colorless solutions of n-methylmorpholine oxide

A method of purifying acifluorfen to achieve a purity of greater than about 85% by weight involves heating to dissolution a solution of an acifluorfen crude wet cake and at least one solvent from the group of 1,2-dichlorobenzene, monochlorobenzene, o-xylene and p-xylene, with the solution having from about 10 to about 30 weight percent of acifluorfen crude wet cake. The-solution is then cooled until crystals of purified acifluorfen form. The crystals are then filtered at a temperature within the range of from about 0.degree. to about 30.degree. C. The filtered crystals are then recovered.

Method of purifying acifluorfen

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Dearborn, MI, United States of America

Mark D Sandison