Wisconsin Alumni Research Foundation

Smith + Nephew

Mark D Markel

William Leo Murphy

Ben Kim Graf

Kobi Iki

William M Ambrisco

Douglas M Lorang

Alan P Gannon

Richard Ranalli

Ryland B Edwards, Iii

Mathew Erle Mitchell

Jae Sung Lee

Yan Lu

Thomas Rockwell Mackie

Peter Muir

Orrin D Lokken

George Petry

Matthew E Mitchell

Jae-Sam Lee

Marie Meyer

Mandi J Lopez

William W D Hagquist

Geoffrey Baer

Robert Swader

The present disclosure generally relates to biodegradable and bioresorbable materials having a mineral layer on the surface of the material. More particularly, the disclosure relates to biodegradable and bioresorbable orthopedic devices having a degradable mineral layer on the surface thereof that can be used as a delivery vehicle for biological substances. Also provided are various methods of using the mineralized devices in tissue regeneration, including bone tissue engineering, and methods for producing the mineralized devices.

Biologically active sutures for regenerative medicine

An electrosurgical instrument for ablating cartilage while limiting collateral damage includes a non-conducting head with a small electrically conductive surface. The head of the instrument is coupled to a shaft by a flexible portion. The flexible portion biases the electrically conductive surface towards a tissue surface. The head is pivotably coupled to the shaft such that the electrically conductive surface is oriented substantially parallel to the tissue surface as the head slides across the tissue surface. A method of performing electrosurgery includes positioning the electrically conductive surface adjacent to the tissue surface, and sliding the shaft across the tissue surface with the head pivoting such that the electrically conductive surface is oriented substantially parallel to the tissue surface.

Cartilage treatment probe

A CT machine for scanning a stationary patient may provide for two-bar linkage articulated arms to move a CT gantry in an arbitrary trajectory. In one embodiment, the gantry may fit within a cavity to expose a central platform, which may support a patient for vertical scans in which the gantry housing rises from the cavity after the patient is so positioned.

CT machine for multi-angle scanning of stationary patients

A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a hydroxyapatite-binding portion and a biomolecule-derived portion. The modular peptides have improved non-covalent binding to the surface of the HA-based materials, and are capable of initiating osteogenesis, angiogenesis, and/or osteogenic differentiation.

Methods of decorating hydroxyapatite biomaterials with modular biologically active molecules

A system for growing tissue based upon layers of an inorganic extracellular matrix, wherein each layer of the inorganic matrix is designed to dissolve at a separate rate and result in sequential growth factor delivery upon its dissolution.

Tissue regeneration system

Decorating hydroxyapatite biomaterials with modular biologically active molecules

Controlled release of biopharmaceutical growth factors from a hydroxyapatite coating on a bioresorbable interference screw used in cruciate ligament reconstruction surgery on a human. Biologically active scaffolds, such as interference bone screws used for ligament fixation, made by growing calcium phosphate-based hydroxyapatite coatings on bioresorbable poly(&#x3b1;-hydroxy ester) scaffolds that provide controlled mineral dissolution and controlled release of bone morphogenetic protein-2. The biologically active scaffold provides improved bioavailability of BMP-2 growth factor that in turn provides enhanced graft-bone healing in the tibial bone tunnel. The coating method uses surface hydrolysis and modified simulated body fluid incubation which does not require solvent or heat and is conducted at room temperature.

Controlled release of biopharmaceutical growth factors from hydroxyapatite coating on bioresorbable interference screws used in cruciate ligament reconstruction surgery

An electrosurgical instrument includes a shaft, a flexible portion, and a head coupled to the shaft through the flexible portion and pivotably coupled to the flexible portion. The head includes a non-conductive surface and an electrically conductive surface. The flexible portion is configured to bias the non-conductive surface and the electrically conductive surface towards a tissue surface, such as cartilage. The non-conductive surface may include a material having a thermal conductivity less than or equal to about 30 W/m*K and/or a volume resistivity greater than or equal to about 1&#xd7;10ohm*cm. The non-conductive surface may include a ceramic such as Macor&#xae; ceramic, ZTA ceramic, and/or 99.5% alumina ceramic.

A goniometer (also sometimes referred to as an arthrometer, fleximeter, or pronometer) for measuring the range of motion of an animal knee includes an anchor platform to which an animal's upper leg (femur) may be affixed, and a mobile platform to which the animal's lower leg (shin and tibia) may be affixed so that the upper and lower leg are situated along a common axis. The mobile platform is preferably movable in two degrees of freedom (translational and rotational) about the anchor platform so that the relative motion of the platforms causes the upper and lower leg to move about the intermediate knee joint. A force transducer (such as a spring scale) and/or a torque transducer (such as a common torque wrench) may be used to obtain measurements of the laxity of the knee joint.

Veterinary goniometer for testing of animal leg joints

Growing community of inventors

Middleton, WI, United States of America

Mark D Markel