Mdr Group, Inc.

Mark D Allen

John M Blackmore

Phillip E Pennell

This invention relates to an improved viscoelastic fluid or gel for use in general surgery and also more specifically in spine and neurosurgery and also in surgery dealing with reproductive organs. The invention encompasses the method of delivering to a surgical wound an implant composition having up to about a 21/2% by weight of carboxymethylcellulose (CMC) and at least about a 0.5% by weight polyethylene oxide (PEO) in a physiologically acceptable mixture.

Viscoelastic fluid for use in spine and general surgery and other

This invention relates to an improved viscoelastic fluid or gel for use in surgery and other therapies which consists of polyethylene oxide in selected concentrations not to exceed approximately 15% (15,000 ppm), contained in a physiologic balanced salt solution. The PEO may also be used in conjunction with viscosity enhancers which also act as heat stabilizers such as methylcellulose and its derivatives, polyvinyl pyrrolidone of polyvinyl alcohol or in conjunction with elasticizes such as low molecular weight polyethylene glycols or polypropylene glycols or in conjunction with gelation modifiers. These mixtures may be modified to increase retention time in the body by crosslinking with the use of material like dimethyl urea. The invention encompasses the novel method of protecting and lubricating the corneal tissues during surgery with uses of different concentrations of the same solution introduced simultaneously to protect the inner cornea while periodically irrigating the outer cornea, all without obscuring the surgeon's view of the site. This invention also prevents the development of wound adhesion and has many utilizations in orthopedics.

Viscoelastic fluid for use in surgery and other therapies and method of

This invention relates to an improved viscoelastic fluid or gel for use in surgery and other therapies which consists of polyethylene oxide in selected concentrations not to exceed approximately 15% (15,000 ppm), contained in a physiologic balanced salt solution. The PEO may also be used in conjunction with viscosity enhancers which also act as heat stabilizers such as methyl cellulose and its derivatives, polyvinyl pyrrolidone or polyvinyl, alcohol or in conjunction with elasticizers such as low molecular weight polyethylene glycols or polypropylene glycols or in conjunction with gelation modifiers. These mixtures may be modified to increase retention time in the body by crosslinking with the use of materials like dimethylol urea. The invention encompasses the novel method of protecting and lubricating the corneal tissues during surgery with uses of different concentrations of the same solution introduced simultaneously to protect the inner cornea while periodically irrigating the outer cornea, all without obscuring the surgeon's view of the site. This invention also prevents the development of wound adhesion and has many utilizations in orthopedics.

This invention relates to a UV-blocked viscoelastic vitreous substitute for use in ophthalmic surgery comprising a hydroxy alkyl-substituted cellulose modified with a UV-absorbent molecule covalently bonded thereto having the type formula: ##STR1## where R.sup.1 is selected from the group consisting of H and OH; R.sup.2 is selected from the group consisting of H, OH or OR where R is any alkyl group; and, R.sup.3 is selected from the group consisting of H, SO.sub.3, OSO.sub.2 X where X is a leaving group.

Growing community of inventors

Lakewood, CO, United States of America

Mark D Allen