Wyeth

Bristol-myers Squibb Compnay

American Home Products Corporation

Mark Cockett

Huai-Ping Ling

Patricia Tyson Sokol

Daniel Wayne Dilks

Chandra S Ramanathan

Stephen Kohl Doberstein

Sharon J Rosenzweig-Lipson

David S Howland

Kathleen H Young

Terry Stouch

Nicholas J Lodge

Karen L Marquis

Kevin Fitzgerald

Jenny Kopczynski

Lisa Moore

Rachel M Kindt

The present invention provides methods that are useful for the treatment or prevention of smooth muscle disorders such as urinary incontinence and compounds that are useful in such methods.

Methods of screening for agents that modulate the interaction of RGS and G&#x3b1;q and urinary incontinence

A transgenic rat containing in its genome a nucleotide sequence encoding a Ga subunit protein, which Ga protein subunit is uncoupled from regulation by Regulators of G-Protein Signaling (RGS) proteins, which Gx subunit protein is eventually the dominant-negative G188S mutant of Gax9, which nucleotide sequence is operatively associated with a neuron-specific expression control sequence, wherein the transgenic rat expresses the GA subunit protein in neural cells resulting in extended D-protein coupled receptor signaling mediated by the Ga subunit protein.

Transgenic animal

Novel human Kv4.3 polypeptides, polynucleotides which encode these polypeptides, and methods for producing these polypeptides are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided.

Human potassium channel polynucleotides and polypeptides and uses thereof

Human potassium channel polynucleotide and polypeptides and uses thereof

Growing community of inventors

Newtown, PA, United States of America

Mark Cockett