Ardea Biosciences, Inc

Other

Gulfstream Aerospace Corporation

Jimmy G. Cook

Mark Chapman

Bryan Williams

Barry D Quart

Brenden Autry

Jeffrey Miner

Mauro Mori

Chunrong Yu

Laurence Hastings Bloxham

Dillon Volk

Alex Adjei

An aircraft includes the aircraft component. The aircraft component includes an outer skin portion, a plurality of major stiffeners, and a plurality of minor stiffeners. The outer skin portion has an interior side and an exterior side configured to define an exterior boundary of the aircraft. The major stiffeners are integral with the outer skin portion and extend out from the interior side. The major stiffeners are configured to resist global deflection of the aircraft component in response to a bird strike on the aircraft component. The minor stiffeners are disposed between the major stiffeners, are integral with the outer skin portion, and extend out from the interior side. The minor stiffeners are configured to resist perforation of the aircraft component in response to the bird strike on the aircraft component.

Unified canopies for aircraft

A composite reinforcement structure including a first skin having a first end and a second end and a second skin having a first end and a second end. The first end of the first skin and the first end of the second skin are coupled. A corrugated spar is disposed between the first skin and the second skin and is bonded to the first skin and the second skin.

Composite reinforcement structures and aircraft assemblies comprising composite reinforcement structures

The present invention relates to the field of oncology and provides compositions and methods for treating specific cancers, including non small cell lung cancer, breast cancer, thyroid cancer, pancreatic cancer, colon cancer, melanoma, hepatoma and adenocarcinoma. Particularly, compositions and methods involving administration, either simultaneously or sequentially, of pharmaceutical combinations comprising (S)&#x2014;N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1 -(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide with other compounds, to patients suffering from cancer are described.

Pharmaceutical combinations for treatment of specific cancers

This invention concerns combinations of inhibitors of MEK, Raf protein kinases, and other kinases including VEGFR1-3 and PDGFR-&#x3b2;. This invention also concerns pharmaceutical compositions comprising the compounds described herein and methods of use of the compounds and compositions described herein, including the use in the treatment and/or prevention of cancer and other hyperproliferative disorders.

Combinations of MEK inhibitors and Raf kinase inhibitors and uses thereof

The present invention relates to the field of oncology and provides compositions and methods for treating specific cancers, including non small cell lung cancer, breast cancer, thyroid cancer, pancreatic cancer, colon cancer, melanoma, hepatoma and adenocarcinoma. Particularly, compositions and methods involving administration, either simultaneously or sequentially, of pharmaceutical combinations comprising (S)&#x2014;N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide with other compounds, to patients suffering from cancer are described.

A foot cleaning device for use by a user in a bathing chamber. The device, which will preferably be situated on the floor or bottom surface of the bathing chamber, includes a reservoir to hold a cleaning fluid that is dispensed when the user steps upon the device. Bristles are provided on wall surfaces of the reservoir, and scrubbing arcs may further be included to assist in cleaning and scrubbing of a foot of the user.

Foot cleaning device

The Dual Spectrum Illumination System (DSIS) is a modular light source having two independent emitters of optical radiation. A halogen bulb provides a high intensity visible beam. The second source of emissions is a ring of light emitting diodes (LED). The LED ring can be configured to supply area illumination, beam illumination, or a combination of area and beam illumination. The spectrum emitted by the LED is selectable from the wide range of commercially available diodes. The illumination system provides a beam and infrared area lighting using 21 high power, 6 watt, LEDs emitting at 880 nanometers mounted on the ring. Illumination control electronics are provided on a printed circuit assembly to provide the diodes with the correct current and voltage. A second embodiment of the invention is as a direct replacement for aircraft landing lights, mobile vehicle head lights, and any other situation requiring beam illumination. This embodiment of the DSIS provides high intensity beams of visible light and infrared light and is particularly suited for U.S. Air Force covert operations. The system includes a mounting plate having a plurality of receptacles that receive the LEDs. Shield are provided that each surround a portion of selected receptacles in order to block infrared light that would otherwise impinge upon the cockpit of the aircraft.

Light shield for an illumination system

The Dual Spectrum Illumination System (DSIS) is a modular light source having two independent emitters of optical radiation. A halogen bulb provides a high intensity visible beam. The second source of emissions is a ring of light emitting diodes (LED). The LED ring can be configured to supply area illumination, beam illumination, or a combination of area and beam illumination. The spectrum emitted by the LED is selectable from the wide range of commercially available diodes. The illumination system provides a beam and infrared area lighting using 21 high power, 6 watt, LEDs emitting at 880 nanometers mounted on the ring. Illumination control electronics are provided on a printed circuit assembly to provide the diodes with the correct current and voltage. A second embodiment of the invention is as a direct replacement for aircraft landing lights, mobile vehicle head lights, and any other situation requiring beam illumination. This embodiment of the DSIS provides high intensity beams of visible light and infrared light and is particularly suited for the U.S. Air Force covert operations.

Growing community of inventors

San Diego, CA, United States of America

Mark Chapman