Millipore Corporation

Emd Millipore Corporation

Mark Carroll

Jeremy Perreault

Aaron Noyes

Stephen Proulx

Joseph M Almasian

Brian Pereira

David DeCoste

George T Perivolotis

Chau Nguyen

Frank M Lentine

Kevin G McInerney

David McInerney

Giulia Paliotti

John Leonard Burns, Jr

Frank Lentine

The present invention provides an automated system and method for maintaining compaction, and therefore increased efficiency, of a media bed within a chromatography column. In the preferred embodiment, an adjustment assembly is slidingly engaged inside one end of the column such that it can be moved along the column's major axis. When idle, the force exerted on this end is equal to the compression on the media. When the column is actively processing chromatographic fluid, this exerted force can be expressed as the sum of the compression on the media, and the force of the fluid being processed. This total force and the fluid pressure are monitored using a load cell and a pressure sensor respectively. The compression force operating on the media bed is then computed based on these measurements and compared to the optimal value. The position of the adjustment assembly within the column is then modified in response to changes in the measured compression force.

System for automated compression of chromatography columns

The present invention provides an automated system and method for packing chromatography columns. In one embodiment, the system first determines the type of media that is present in the column, and uses this information to generate an automated procedure to pack the specific media type. In a second embodiment, the media type is made known to the system, such as via input from the operator. The system then uses this information, in the same manner as in the first embodiment, to generate an automated procedure to pack the specific media type. Finally, in a third embodiment, parameters such as column height and rate of compression are made known to the system, such as via input from the operator. The system then packs the column in accordance with these supplied parameters.

Intelligent system and method for automated packing of chromatography columns

The present invention relates to a filter element having a non-porous extrusion laminated strip formed on at least one edge and at least one side of a membrane. The strip is used to provide a means for ensuring a good bond between the filter element and the material into which it is potted. The strip is formed by the use of one or more extrusion heads that apply molten or softened polymer to one or both of the surfaces of the filter in a width and height desired. The strip is then subjected to pressure such as through a nip to at least partially embed the polymer strip into the filter pores so as to create a strong mechanical bond between the strip and the filter element. Additionally, it allows for the simultaneous formation of more than one membrane with the edge lamination at the same time.

Laminated edge filter structure and method of making

Filter cartridge container

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Londonderry, NH, United States of America

Mark Carroll