Merck + Co., Inc.

Sirna Therapeutics, Inc.

Merck Sharp + Dohme Corp.

Mark Cameron

Ulf H Dolling

Ian Frank Cottrell

Matthew G Stanton

John M Williams

Weimin Wang

Ronald B Jobson

Lu Tian

Michael Stewart Ashwood

Jennifer R Davis

Karel M Brands

Andrea R Geiser

Antony J Davies

Vladislav V Telyatnikov

Linghang Zhuang

Melissa S Egbertson

John S Wai

Joseph E Lynch

David Askin

Philip J Pye

R Scott Hoerrner

Michael J Kaufman

Debra S Perlow

David Hands

Yao-Jun Shi

Wei Han

Shyam B Karki

&Ouml;rn Almarsson

Remy Angelaud

David R Lieberman

Michael A Robbins

Maneesh J Nerurkar

Danny Mancheno

Brian Cchristopher Bishop

Bruce S Foster

Rowena D Ruzek

The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with siRNA, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo.

Cationic lipids with various head groups for oligonucleotide delivery

Hydroxy (tetra- or hexa-)hydronaphthyridine dione compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein a, R1?, R2?, R3?, R4? and R5? are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. 

HIV integrase inhibitors

Salt form of a conjugate useful in the treatment of prostate cancer

A process of synthesizing a compound of the formula 1: ##STR1## is described. A compound of the formula 2: ##STR2## is reacted with diphenylphosphinic chloride to activate the carboxylic acid group, and then reacted with methanesulfonyl chloride to produce a compound of formula 4: ##STR3## Compound 4 is then reacted with a group II metal sulfide source in water to produce a compound of formula 1.

Process for synthesizing carbapenem side chain intermediates

The present invention relates to a process for the preparation of azaindole derivatives of the formula ##STR1## wherein Q is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.1-6 alkoxy, hydroxy, aryl or arylC.sub.1-4 alkyl;

Chemical synthesis of azaindoles

Growing community of inventors

Brick, NJ, United States of America

Mark Cameron