Gyroscope Therapeutics Limited

Orbit Biomedical Limited

Alcon, Inc.

Janssen Biotech, Inc.

F. Hoffmann-la Roche Ag

Mark C Tsai

Michael F Keane

Isaac John Khan

Thomas Edward Meyer

Daniel W Price

Brendan J Oberkircher

Daniel J Abbott

Joseph Henry Contiliano

Allen C Ho

Scott Albert Uhland

Benjamin L Ko

Clinton W Denlinger

Daniel James Prenger

James G Lee

Geoffrey King

Brian M Gatton, Jr

Denis P Turner

Richard A Rossback

Jr Gatton Brian M

An apparatus has a first fluid conduit, a second fluid conduit, a connector member, an first tubular member, a second tubular member, and an inner cannula. The connector member has first and second passageways in which the first and second fluid conduits are positioned, respectively. A portion of the second tubular member is positioned within the lumen of the first tubular member. A proximal portion of the inner cannula is fixedly secured within the lumen of the first tubular member. The inner cannula lumen is in fluid communication with the first and second fluid conduits via the lumen of the first tubular member and the lumen of the second tubular member. The inner cannula may be inserted into the subretinal space of a human eye to deliver a leading bleb of fluid and then deliver a therapeutic agent, without having to withdraw the inner cannula from the subretinal space between the acts of delivering the leading bleb delivering the therapeutic agent.

Therapeutic agent delivery device with convergent lumen

A system for storing and delivering a predetermined amount of fluid includes a syringe including a barrel, a flange disposed at the proximal end of the barrel, and a plunger assembly configured to be received in the lumen of the barrel. The plunger assembly includes a piston and a plunger rod. The plunger rod is removably couplable to the piston at the distal end of the plunger rod and includes a thumb press flange at the proximal end of the plunger rod. The system further includes a stop feature that is removably couplable to the syringe or the plunger assembly. The stop feature is configured to arrest distal advancement of the plunger assembly relative to the syringe when the plunger assembly reaches a predetermined position relative to the syringe. The stop thus ensures that a predetermined amount of fluid remains in the barrel.

Therapeutic agent delivery device

An apparatus includes a pad assembly, an injector assembly, an injector driver, and a fluid source. The pad assembly is sized and configured to be placed on a forehead of a patient. The injector assembly includes a body, a flexible cannula, and a needle. The body is configured to be removably secured to the pad assembly. The cannula is sized to be inserted through an incision in an eye of a patient. The needle is slidably disposed in the cannula. The injector driver is operable to drive the needle longitudinally relative to the flexible cannula. The fluid source assembly is in fluid communication with the needle.

Injection device for subretinal delivery of therapeutic agent

A relatively stiff syringe pressure applicator having a pair of ears, the ears are overmolded with a relatively soft elastomer. A port extends through the syringe pressure applicator and is connected to friction fittings on either side of the pressure applicator. The external fitting is suitable for connecting to a source of pressurized air. The other fitting is sized and shaped to receive an elastomeric seal that may be inserted into the open end of a syringe to seal the syringe air tight.

Syringe pressure applicator

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Chalfont, PA, United States of America

Mark C Tsai