American Cyanamid Company

Bristol-myers Squibb Compnay

Mark C Manfredi

Michael A Guaciaro

Gary Mitchell Karp

Philip Mark Harrington

Alvin D Crews, Jr

Lawrence G Hamann

Michael E Condon

Alvin Donald Crews, Jr

Yingzhi Bi

Alvin Donald Crews

James Clifford Sutton

Alexandra A Nirschl

Jeffrey A Robl

David John Augeri

William N Washburn

Peter J Wepplo

Keith Douglas Barnes

Gavin David Heffernan

David Allen Hunt

Andres S Hernandez

Marianne Carlsen

Sergio I Alvarado

Michael Vernie Cossette

Gregory J Haley

Ligaya Simpkins

Richard Anthony Rampulla

Gary Allen Meier

Billy Gene Bullock

The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I. 

Substituted thieno[3,2-d]pyrimidinones as MCHR1 antagonists and methods for using them

Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein

Sulfonylpyrrolidine modulators of androgen receptor function and method

The invention provides for a pharmaceutical composition capable of modulating the androgen receptor comprising a compound of formula I wherein R, R, R, X, Y, Z and G are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia, and also provided are pharmaceutical compositions containing such compounds.

Open chain prolyl urea-related modulators of androgen receptor function

The present invention relates to novel compounds useful in the treatment of androgen receptor associated conditions, such as age-related diseases, pharmaceutical compositions containing at least one of the compounds of the present invention and methods of treating a patient in need of therapy for an androgen receptor associated condition by administering a therapeutically effective amount of at least compound of the present invention.

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There are provided 3-(1,2-benzisothiazol- and isoxazol-5-yl)-2,4(1H,3H)-pyrimidinedione or thione compounds of formula I and 3-(1,2-benzisothiazol- and isoxazol-5-yl)-4(3H)-pyrimidinone or thione compounds of formula II ##STR1## Further provided are compositions and methods comprising those compounds for the control of undesirable plant species.

3-(1,2-Benzisothiazol- and isoxazol-5-yl)-2,4(1H,3H)-pyrimidinedione or

There is provided a 1-(3-heterocyclylphenyl)-s-triazine-2, 4,6-oxo or thiotrione compound having the structural formula I ##STR1## Further provided are a composition and a method comprising that compound for the control of undesirable plant species.

1-(3-heterocyclyphenyl)-s-triazine-2,4,6-oxo or thiotrione herbicidal

1-(3-heterocyclyphenyl)-S-triazine-2,6,6-oxo or thiotrione herbicidal

There is provided a 1-(3-heterocyclylphenyl)-s-triazine-2,4,6-oxo or thiotrione compound having the structural formula I ##STR1## Further provided are a composition and a method comprising that compound for the control of undesirable plant species.

1-(3-heterocyclphenyl)-s-triazine-2,4,6-oxo or thiotrione herbicidal

1-(3-heterocyclylphenyl)-s-triazine-2,4,6-oxo or thiotrione herbicidal

1-(3-heterocyclylphenyl)-S-triazine-2,4,6-oxo or thiotrione herbicidal

1-(3-heterocyclylphenyl)-s-triazine-2,4,6-oxo or thiortione herbicidal

There is provided a 6-heterocyclyl-1-(substituted phenyl)benzotriazole compound having the structural formula I ##STR1## Further provided are a composition and a method comprising that compound for the control of undesirable plant species.

6-heterocyclyl-1-(substituted phenyl) benzotriazole herbicidal agents

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Hamilton, NJ, United States of America

Mark C Manfredi