Mologic Limited

Church Dwight & Co., Inc.

Mark Burnapp

Paul James Davis

Mark James Davis

Paul Duesbury

Sandra Hemmington

Mark Davis

Julie Thompson

Brett Cochrane

An enzyme detection product for detecting the presence of an enzyme in a sample. The product includes: a reaction zone for receiving the sample; a visualization zone for presenting a signal in response to the detection of the activity of the enzyme; and a membrane. The membrane is interposable between the reaction zone and the visualization zone and prevents passage from the reaction zone to the visualization zone the components having a size greater than a threshold size. The reaction zone includes a reactant capable of reacting with the enzyme in order to generate a reaction product having a size less than a threshold size.

Method for detecting the presence of a protease enzyme in a sample

An enzyme detection product () for detecting the presence of an enzyme in a sample. The product () comprises: a reaction zone () for receiving the sample; a visualization zone () for presenting a signal in response to the detection of the activity of the enzyme; and a membrane (). The membrane () is interposable between the reaction zone () and the visualization zone () and prevents passage from the reaction zone () to the visualization zone () the components having a size greater than a threshold size. The reaction zone () comprises a reactant capable of reacting with the enzyme in order to generate a reaction product having a size less than a threshold size.

Enzyme detection

A binding assay product () for detecting the presence of an analyte in a sample comprising a labelling module (), a label, a capture module () and a visualization module (). The labelling module () comprises a first binding component capable of binding the analyte. The label is connectable to the first binding component. The capture module () comprises a second binding component capable of binding the analyte. The visualization module () is for detecting the first binding component connected to the label and bound to the second binding component via the analyte. The labelling module and the capture module comprise a fluid conducting medium in which the binding components are embedded. The labelling module (), the capture module () and the visualization module () together define a flow path along which the sample is capable of flowing.

Binding assay

A method of detecting a protease in a sample. The method comprises providing an analyte degradable by the protease. The analyte is contacted with the sample. The degradation products of the analyte or the residual undegraded analyte is detected in a binding assay.

Protease detection

A diagnostic test device comprises means for sampling a liquid biological sample and means for reacting the sample with at least one reagent to provide one or more visible indicia. The device also comprises an optical detector for detecting the presence of the one or more indicia. The device also comprises means for causing at least part of the optical detector to move over the one or more indicia.

Diagnostic test device

A diagnostic test device comprising means for sampling a liquid biological sample, means for reacting the sample with at least one reagent to provide one or more visible indicia and an optical detector for detecting the presence of said one or more indicia, the device further comprising a releasable tether which is released by contact with the liquid sample, thereby to cause the optical detector to detect the said one or more indicia.

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Bedfordshire, United Kingdom

Mark Burnapp