Helmholtz-Zentrum Fuer Infektionsforschung Gmbh

Helmholtz-Zentrum Fur Infektionsforschung Gmbh

Mark Broenstrup

Verena Fetz

Christoph Wittmann

Werner Tegge

Stephan Huettel

Wera Collisi

Haiyu Hu

Galina Sergeev

Bushra Rais

Philipp Klahn

Katrin I Mohr

Kevin Ferreira

Jost Van Duuren

Blanka Karge

The present invention is directed to novel natural product-derived ratjadone-based compounds useful as payloads (or toxins) in drug-conjugates constructs with cell target binding moieties (CTBM) and payload-linker compounds useful in connection with drug conjugates. The present invention further relates to new ratjadone compositions including the aforementioned payloads, payload-linkers and drug conjugates, and methods for using these payloads, payload-linkers and drug conjugates, to treat pathological conditions including cancer, inflammatory and infectious diseases.

Targeted cytotoxic ratjadone derivatives and conjugates thereof

The present invention relates to new compounds comprising a siderophore moiety as well as a core structure able to chelate a metal ion. Optionally, the compounds may have additionally a moiety with a functional element including a marker molecule, a bioactive agent, an activity based probe suitable to monitor the aberrant expression or activity of proteins involved in the initiation and progression of bacterial infection, or a compound useful for bacterial inhibition. In a further aspect, the present invention provides a pharmaceutical composition containing said compound, for example, said pharmaceutical composition is an antibiotic. Additionally, the present invention relates to the use of said compounds in diagnostic methods, in particular, imaging methods including SPEC, PET or MRI. In an embodiment of the present invention, the compound is part of a theranostic composition having both, therapeutic as well as diagnostic activities.

1,4,7,10-tetrazacyclododecane based agents to target bacteria and its use

A method for determination of the growth rate of biofilm using an electrical impedance analyses is disclosed. The method comprises the steps of: bringing a culture medium fluid in contact to an electrode structure, having biofilm grown within the fluid culture medium with the biofilm arranged in distance to the electrodes structure, so that the fluid culture medium is placed between the growing biofilm and the electrode structure; measuring the impedance of the electrodes structure over a monitoring time, and determining the growth rate of the biofilm as a function of the reduction rate of the impedance values measured on the electrode structure.

Method and measuring device for determination of the growth rate of biofilm

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Braunschweig, Germany

Mark Broenstrup