Pfizer Corporation

Bend Research, Inc.

Sartorius Ag

Mark B Chidlaw

Dwayne Thomas Friesen

William John Curatolo

Avinash G Thombre

Ronald Arthur Beyerinck

Leah Elizabeth Appel

Kelly L Smith

Daniel J Brose

Kenneth C Waterman

Donald J Kelly

Michael B Fergione

Michael C Roy

Danni Supplee

Leah A Appel

Carol A Thornton

A controlled release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating around the core is water-permeable, water-insoluble and has at least one delivery port therethrough. A variety of formulations having specific drug release profiles are disclosed.

Hydrogel-driven drug dosage form

A controlled release dosage form for sertraline has a core comprising a sertraline-containing composition and a water-swellable composition wherein the water-swellable composition is in a separate region within the core. A coating around the core is water-permeable, water-insoluble, and has at least one delivery port therethrough. In one embodiment, the dosage form releases sertraline to the use environment at an average rate of 6 to 10 wt % per hour from the second to the twenth hour after introduction to a use environment and less than about 25 wt % for the first two hours and at least 70 wt % by the twelfth hour, where the percentages correspond to the mass of drug released from the tablet divided by the total mass of drug originally present in the tablet. In another embodiment, the dosage form releases less than about 25 wt % of sertraline to the use environment by the second hour after introduction of the dosage form to the use environment, and delivers at least 25 wt % from the eighth to the twenty-fourth hour.

Hydrogel-driven layered drug dosage form

Multi-step methods of making a non-skinned isotropic microfiltration membrane, the common steps of which include heating a PVDF-type casting dope above its cloudpoint, forming a film, and immersing the film in a gelation bath.

Process of making polyvinylidene fluoride membranes

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Bend, OR, United States of America

Mark B Chidlaw