Agilent Technologies, Inc.

University of Washington

The Uab Research Foundation (the University of Alabama at Birmingham)

Hewlett-Packard Company

Avago Technologies Fiber IP (Singapore) Pte. Ltd

Mark Andrew Troll

Jens H Gundlach

Mikhail Pavlenok

Thomas Z Butler

Michael Niederweis

Suja Sukumaran

Douglas J Dellinger

SueAnn C Dahm

Julie Elizabeth Fouquet

Dale W Schroeder

Stefano Schiaffino

Douglas Michael Baney

Andreas N Dorsel

Datong Chen

David K Donald

Robert A Ach

John W Sadler

Shalini Venkatesh

Richard Earl Haven

David James Anvar

William Ian McAlexander

Frederick A Stawitcke

Diane D Ilsley

J Robert Mitchell

Bertil Hille

MSP NANOPORES AND RELATED METHODS

Provided herein areporin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression.

MSP nanopores and related methods

Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression.

Msp nanopores and related methods

Optical systems such as, for example, optical switches, are disclosed comprising a solid component and a refractive index-matching liquid composition interfaced with the solid component. The liquid composition has a refractive-index that is substantially equal to that of the solid component. In one approach the liquid composition is a saturated cyclic compound consisting essentially of carbon and hydrogen and optionally oxygen such as, e.g., cyclic alkanes, alcohols or ketones. In another approach the liquid composition is benzene substituted with one or more electron-donating groups attached directly to the ring and one of more fluoro groups attached to the ring or to the electron-donating groups. In yet another approach the liquid composition is a combination comprising one or more of benzene or substituted benzene and optionally at least one of an alkane or substituted alkane having a boiling point less than about 130&#xb0; C. Also disclosed are methods for preparing a liquid composition having a predetermined refractive index at a predetermined temperature and methods for transmitting optical signals.

Optical systems and refractive index-matching compositions

Bubble stability within an optical switch is enhanced by controlling the expansion or movement of a bubble from a liquid-containing trench into available adjacent spacing. Typically, the adjacent spacing is formed between an optical waveguide substrate and a heater substrate, where the heater substrate includes a microheater for forming the bubble. The bubble enhancement is provided by intentionally altering surface features along at least one of the substrates.

Bubble stability in an optical switch

A system for manipulating optical signals in an optical switch utilizes a piezoelectric membrane. The membrane is selectively enabled to switch among an outward position, an inward position and a relaxed orientation in relation to a sidewall of a trench that is provided as part of the switch. The membrane is in fluidic communication with an intersecting gap of the trench that crosses a first input waveguide and a first output waveguide. Displacing the membrane to a first position causes the gap to be filled with an index-matching liquid such that light from the first input waveguide is transmitted to the first output waveguide. Alternatively, displacing the membrane to a second position causes the gap to be filled with a gaseous bubble, resulting in a refractive index mismatch, such that the light from the first input waveguide is diverted at the gap. In another embodiment, there are two membranes utilized for manipulating optical signals.

Piezoelectrically driven, liquid-actuated optical cross-bar switch

A compact, broadband laser source is realized by using a rare earth dopant to define a laser gain spectrum and by using holographic imprinting techniques to form a wavelength selection element for selecting a particular wavelength from within the gain spectrum. Artificial broadening of the gain spectrum can be achieved by establishing varied (e.g., randomized) domains of space charge within a rare earth-doped laser gain medium. Compactness can be enhanced by fabricating the laser gain medium and wavelength selection elements within a single member, such as a photorefractive crystal substrate. Flexibility in the selection of a wavelength can be obtained by holographically imprinting multiple sets of wavelength selection elements.

Rare earth-doped medium with photorefractive grating as compact laser source

A system for manipulating optical signals in an optical switch utilizes a light-absorbing region. The region efficiently converts light to thermal energy and is in thermal communication with an index-matching fluid disposed within an intersecting gap between a first input optical waveguide and a first output optical waveguide. In one embodiment, exposing the region to optical radiation elevates the temperature of the fluid within the gap, resulting in vaporization of the fluid into gas. Filling the gap with gas creates a refractive index mismatch that causes light from the first input waveguide to be diverted to a second output waveguide. In another embodiment, the manipulation of optical signals is achieved by exposing a light-absorbing fluid to the source radiation.

Optical switch controlled by selective activation and deactivation of an optical source

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Seattle, WA, United States of America

Mark Andrew Troll