Transmedics, Inc.

Transmedic, Inc.

Mark Anderson

Waleed H Hassanein

Tamer I Khayal

Richard Bringham

John Sullivan

Scott W Newell

Stanley Kyi

Robert Havener

Robert Fishman

Ihab Abdel Fattah

Anas Abdelazim

Doug Harriott

Matthew De Remer

Paul Murray

Michael Van Driel

Ron Taylor

Ahmed Elbetanony

Jeff Barnes

Greg Ritchie

Tom Bishop

Thomas H Bishop

Ronald Taylor

Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

Systems and methods for ex vivo lung care

The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.

Ex vivo organ care system

The disclosure generally relates to a system for perfusing an ex-vivo liver including a pump configured to pump a perfusion fluid through a perfusion circuit, the pump in fluid communication with a hepatic artery interface and a portal vein interface; an oxygenator; a heater; an inferior vena cava interface in fluid communication with an inferior vena cava of the ex-vivo liver; and a reservoir configured to receive the perfusion fluid from the inferior vena cava of the ex-vivo liver and store a volume of fluid.

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Danvers, MA, United States of America

Mark Anderson