Simplify Medical Pty Limited

Neucoll, Inc.

Mark Alvis

David C Hovda

Yves P Arramon

Roy Fiebiger

Melissa K C Brown

Lisa Metelman

A radiolucent intervertebral prosthesis is implanted in an environment that has been prepared in a manner which enhances radiopacity of the prosthesis and/or the environment. A liquid, powder, or other fluid radiopaque (RO) material, such as iohexol, is introduced into an implantation site, either by directly introducing the material into the site and/or by applying the material to a surface of the implant. The presence of the RO material in the implantation site provides contrast with the material of radiolucent prosthesis while the implantation site is being radiographically imaged, e.g. during fluoroscopic visualization while the prosthesis is being implanted. During implantation, the RO material helps the physician view and manipulate the implant, and after the implantation is complete, the RO material will be resorbed or otherwise lost from the implantation site so that the area returns to a radiolucent condition to facilitate subsequent radiographic imaging when needed.

Methods and systems for enhancing radiographic images of radiolucent implants

The invention provides methods for treating post-surgical articular or incisional pain and/or discomfort in a patient. The invention further provides improved surgical methods and controlled release formulations for treating an articular injury of a joint in a patient, in which a collagen formulation is used in conjunction with a surgical procedure to treat the articular injury or the side effects of the surgical procedure. Collagen formulations of the invention and their use, in addition to the surgical procedure, may provide at least one or more of the following benefits: reduced patient pain, shortened recovery time and/or improved joint condition (including treatment of the underlying articular injury). Moreover, the methods and compositions of the invention can be used in conjunction with essentially any surgical procedure used to treat an articular injury. The invention further provides compositions and methods for treating post-surgical articular or incisional pain in a patient as well as a catheter for use in the methods of the invention.

Methods and compositions for improved articular surgery using collagen

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Santa Cruz, CA, United States of America

Mark Alvis