Other

Pharmacia & Upjohn Company

Mark Allen Mitchell

Robert C Kelly

Eric Jon Jacobsen

Heinrich Josef Schostarez

Martha A Warpehoski

Linda Louise Maggiora

Donald E Harper

Paul A Aristoff

Fan Yang

Richard Allen Nugent

Jeffrey Allen Pfefferkorn

Ke Chen

Lee Andrew Funk

Nancy Anne Wicnienski

Meredith L Greene

Matthew Todd Reding

Rebecca Merry Anderson

Bo Zhang

Thomas J Lindberg

Joseph Delao

Richard Frederick Heier, Iii

A tubular holder with a circular base, a central column, spokes attached to the central columns and ground spikes attached to spokes or bottom of the circular base. In some variations the spokes have orifices for engaging a cup with a cup spike.

Portable umbrella stand and method of use

An artificial turf remover and infill separator comprising an artificial turf removing station, an infill separating station and an artificial turf collection station. The infill separating station comprises rotatable spinning devices comprises corners, wherein each corner comprises chain links. The artificial turf remover and infill separator is utilized by positioning a strip of artificial turf on an angular ramp, conveying the artificial turf over a first pair of rotatable rollers, conveying the artificial turf between a second pair of rotatable rollers, separating infill from the artificial turf via fin-shaped picks, square-shaped rotatable diggers and the rotatable spinning devices, wherein the chain links jostle the infill material from the artificial turf onto a first and second infill collection conveyor belt. The artificial turf is then conveyed over a first and second base roller, between a rear pair of counter-rotating rollers and then wound around a final artificial turf collection roller.

Artificial turf remover and infill separator, and method of use thereof

A pipe holder comprises a handle and a slant piece. The slant piece includes a handle attachment point, a mouth, and a support point. A centerline runs through the mouth and support point. The handle attachment point resides between the mouth and support point, and is configured to point the handle approximately orthogonal to the slant piece centerline. The mouth is sized and shaped to urge a pipe to reside in the mouth substantially orthogonal to the handle and at an angle other than 90 degrees from a plane of the slant piece. When an inserted end of the pipe is inserted through the mouth, a three point stance is formed by the support point, an opposite end of the pipe, and a support end of the handle. The inserted end of the pipe is thereby supported above the ground. The pipe holder is stabilized by stepping on the handle.

Hands free pipe holder

The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present invention provides novel compounds, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment or prevention of HCV infection. The present invention also provides processes and intermediates for the synthesis of these compounds.

Inhibitors of HCV NS5B polymerase

&agr;-hydroxy, -amino, and halo derivatives of &bgr;-sulfonyl hydroxamic acids as matrix metallopropteinases inhibitors

The present invention provides novel thiadiazole derivatives represented by formula I: ##STR1## or pharmaceutical acceptable salts thereof wherein the compounds of the present invention inhibit various enzymes from the matrix metalloproteinase family, predominantly stromelysins, and hence are useful for the treatment of matrix metallo endoproteinase diseases such as osteoarthritis, rheumatoid arthritis, septic arthritis, osteopenias such as osteoporosis, tumor metastasis (invasion and growth), periodontitis, gingivitis, corneal ulceration, dermal ulceration, gastric ulceration, and other diseases related to connective tissue degradation.

Thiadiazole derivatives useful for the treatment of diseases related to

The present invention provides novel thiadiazole amide derivatives represented by formula I ##STR1## The compounds of the present invention inhibit various enzymes from the matrix metalloproteinase family, predominantly stromelysins, and hence are useful for the treatment of matrix metallo endoproteinase diseases such as osteoarthritis, rheumatoid arthritis, septic arthritis, osteopenias such as osteoporosis, tumor metastasis, periodontitis, gingivitis, corneal ulceration, dermal ulceration, gastric ulceration, inflammation and other diseases related to connective tissue degradation.

Thiadiazole amide MMP inhibitors

A compound of formula I or pharmaceutical acceptable salts thereof, ##STR1## wherein R.sub.1 is isopropyl, 2-methylbut-2yl, phenyl, benzyl, or 1H-indol-3ylmethyl; R.sub.2 is n-octyl, phenyl, or phenyl substituted with methoxy, fluoro, or bromo, are matrix metalloproteinase inhibitors.

.alpha.-Amino sulfonyl hydroxamic acids as matrix metalloproteinase

This invention provides some new synthetically obtained compounds of formula I and II ##STR1## which are useful as chemical intermediates. Representative formula I or II compounds have also been shown to possess useful ranges of antitumor activity in standard laboratory animal tests. In addition, the compounds of formula I or II can be linked to monoclonal antibodies, either directly or via known linking group, as a means of selectively delivering the CC-1065 analogs (Compounds of Formula I and II) to those target cells expressing the target antigen and thus selectively eliminating those diseased cells from the animal or human. Further, the compounds of formula I and II can be linked to soluble human CD4 or a soluble human CD4 protein fragment capable of binding to the gp120 envelope protein of the human immuno-virus and thus eliminate virally infected cells.

CC-1065 analogs

An improved system for fabricating convolutely wound tubes includes a supply roll support for supporting a large supply of paperboard, an adhesive applicator for receiving paperboard from the supply roll and applying a coating of adhesive to one side thereof, a cutting station for cutting the paperboard across its length to form sheets of paperboard, and a winding station including a mandrel about which cut sheets of adhesive bearing paperboard are wound into a tubular configuration. As the paperboard is drawn from the supply roll, one of its edges passes sequentially through three corrugating nip rolls, which alternately deform the material of the edge to render it more pliable and flexible. This flexible edge, then, becomes the trailing edge of paperboard sheets that are wound into tubes such that the edge can be easily conformed to the contour of and adhered to the outer surface of the finished tube.

Growing community of inventors

Kalamazoo, MI, United States of America

Mark Allen Mitchell