Cook Medical Technologies LLC

Cook Incorporated

William Cook Europe Aps

Sabin Corporation

Mark Allen Magnuson

Sean Chambers

Fred T Parker, Jr

Jeffry Scott Melsheimer

Siddharth Vad

Arman H Valaie

Keith Milner

Mark Robert Frye

Dharmendra Pal

Shyam Kuppurathanam

Therese J O'Day

Lindsay Koren

Richard Earl Luedemann

Ram H Paul, Jr

Frank J Fischer, Jr

Palle Munk Hansen

James M Carlson

Constantin Cope

Frank J Liu

Frank J Fisher

Keith R Milner

Sean E Chambers

Therese O'DAY

A method for making a graft layer is provided. The graft layer has at least two layers with different porosities. The two layers are applied by electrospinning. The parameters of the electrospinning may be varied when applying the first and second layers in order to achieve different porosities of the first and second layers.

Method for electrospinning a graft layer

A method of treating an intravascular site in a patient includes spraying jets of treatment fluid out of spray orifices formed in an elongate catheter body, and changing an impingement pattern of the treatment fluid on material within the intravascular site in response to a torque induced by a back pressure of the jets. A thrombolysis catheter includes an elongate catheter body having a plurality of spray orifices formed in a body wall, and communicating with a fluid lumen longitudinally extending in the elongate catheter body. The plurality of spray orifices define a torque inducing spray jet pattern, whereby a back pressure of spray jets exiting the spray orifices induces a torque on the elongate catheter body.

Method of treating an intravascular site in a patient, and thrombolysis catheter therefor

Medical devices, as well as methods of treatment and manufacturing such devices, are provided for applying vascular therapy locally within the body vessel. The medical devices include an expandable tubular frame and a sleeve or graft material. The medical devices can be used for local delivery of a therapeutic agent within a body vessel or a tamponade for a lacerated body vessel, while simultaneously allowing perfusion of fluid or blood flow distal of the implanted medical device. The tubular frame of the medical device may have a proximal non-expanding portion and a distal self-expanding support structure. The self-expanding support structure can expand radially outward to urge the graft material to contact the wall of the body vessel. In the expanded configuration, a portion of the device allows fluid flow to continue while the sleeve is against the body vessel wall.

Blood perfusion device

An infusion mechanism for treating an intraluminal site in a patient includes an infusion catheter having an elongate body with a proximal body end defining at least one fluid supply orifice, and a distal body end. The elongate body defines a high head loss lumen in fluid communication with a first set of side ports defining a proximal infusion zone. The elongate body further defines a low head loss lumen in fluid communication with a second set of side ports defining a distal infusion zone.

Infusion mechanism and method

A two-stage method of compressing a stent entails providing an expandable stent () in a radially expanded state. An outward pressure is applied to an inner surface of the tubular framework to support the stent, and a diameter of the stent is reduced to a first compressed diameter (D) while applying the outward pressure. The outward pressure is halted after reaching the first compressed diameter. According to an embodiment in which the stent is balloon-expandable, a delivery balloon catheter () comprising an uninflated balloon in a delivery configuration is inserted into the lumen after halting the outward pressure. The diameter of the stent is reduced to a second compressed diameter (D) smaller than the first compressed diameter to crimp the stent onto the delivery balloon catheter.

Two-stage method of compressing a stent

A method of loading a medical device into a delivery system includes providing a two-stage shape memory alloy at a temperature at which at least a portion of the alloy includes austenite. A stress which is sufficient to form R-phase from at least a portion of the austenite is applied to the medical device at the temperature. A delivery configuration of the medical device is obtained, and the medical device is loaded into a restraining member. Preferably, the delivery configuration of the medical device includes stress-induced R-phase.

Method of loading a medical device into a delivery system

An embolic protection device for deployment in a body vessel is provided for filtering emboli within the body vessel. The embolic protection device generally includes a filter having a plurality of openings formed therethrough and an extraction element configured to be movable with respect to the filter between a non-extraction position and an extraction position. The extraction element is located distally of the filter when in the non-extraction position so as to allow the filter to open into an expanded state to collect the emboli. Additionally, the extraction element is disposed about at least a portion of the filter when in the extraction position so as to close the filter into a collapsed state and to permit the embolic protection device to be extracted from the body vessel.

Embolic protection device

An endovascular device tip assembly and method of making the same, incorporating a radiopaque marker usable with catheters and other suitable endovascular devices is provided. The tip assembly incorporates a radiopaque marker device by providing a counterbore within a primary bore of a tubular tip of an endovascular device. The marker device is fitted securely within the counterbore and the tubular tip is further deformed distally of the marker in order to secure the marker within the device.

Endovascular device tip assembly incorporating a marker device and method for making the same

An expandable stent radially adjustable between a collapsed state and an expanded state. The stent generally includes a main body and a plurality of connector segments. The main body has first and second ends, a longitudinal axis extending from the first end to the second end, and a plurality of ring structures. Each of the plurality of connector segments joins adjacent ring structures. Some ring structures may be connected by a pair of diamond connector segments that define a diamond-shaped portion when the stent is in the expanded state. Some ring structures may be connected by flex connector segments oriented to permit rotation of the second ring structure about the longitudinal axis during radial expansion of the stent.

Radially expandable stent

An embolic protection device includes a basket formed from flexible struts. The struts extend from a first end of the basket to the second end of the basket. The struts form a middle portion of the basket where the struts extend substantially perpendicular to a longitudinal axis, running between the first and second end of the basket.

A device for capturing emboli during treatment of a stenotic lesion in a body vessel is disclosed. The device comprises a base having expanded and collapsed states, and proximal and distal portions. The distal portion has a support portion configured to deploy in the body vessel when the base is in the expanded state. The device further comprises a filter portion disposed on the distal portion of the base. The filter portion includes a lip extending to a filter body to a filter end. The filter portion is configured to engage the support portion when deployed to define an opening of the filter portion for capturing emboli. The device further comprises a collector through which the base is slideably disposed for delivery and retrieval of the device.

Embolic protection device having reduced profile

A process to load a medical device comprising a shape memory material into a delivery system is described herein. According to one aspect, the method includes applying a force to the medical device to obtain a delivery configuration thereof, where the device is at a first temperature within an R-phase temperature range of the shape memory material during application of the force. The medical device is cooled in the delivery configuration to a second temperature at or below a martensite finish temperature of the shape memory material. The force is then removed from the medical device, and the device is loaded into a delivery system. Preferably, the medical device substantially maintains the delivery configuration during the loading process.

Method for loading a medical device into a delivery system

An embolic protection device including a core wire and a basket is disclosed. The basket includes struts and a filter portion formed from a cannula. The struts extend from a first end of the basket to the second end of the basket. The filter portion extends from the struts and is formed unitarily therewith. The filter portion extends between a middle portion of the basket and the second end of the basket and includes openings in the cannula configured to allow the passage of blood cells therethrough.

An embolic protection device includes a foam body attached to a plurality of flexible struts. The foam body has a generally conical geometry and the bottom of the conical geometry having a generally conical recess. The filter portion has pores sized such that blood cells can pass through the foam body, but larger material such as objects would be trapped in the recess. Each strut is attached along the periphery of the foam body and extend from the first end of the foam body to a connection point located proximate the first end.

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Bloomington, IN, United States of America

Mark Allen Magnuson