Portland State University

Mark Allen Lowry

Robert Michael Strongin

Martha Sibrian-Vazquez

Jorge Omar Escobedo-Cordova

Jorge O Escobedo Cordova

Lei Wang

Yixing Guo

Lovemore Hakuna

Jorge Omar Escobedo Córdova

Molecular probes for detecting and imaging pancreatic cancer are disclosed. The probes are modified benzoxanthene fluorophores, which are selectively taken up by pancreatic cancer cells, such as pancreatic ductal adenocarcinoma cells. Embodiments of the disclosed probes are useful for pancreatic cancer detection, therapeutic monitoring, and/or image-guided surgery.

Molecular probes for detection and imaging of pancreatic cancer

Embodiments of compounds for selectively detecting an analyte are disclosed, along with methods and kits for detecting analytes with the compounds. The compounds are bridged viologen conjugates including at least one fluorophore according to the general structure  At least one of R/R, R/R, R/R, R/R, R/R, and/or R/Rtogether form a substituted or unsubstituted cycloalkyl or aryl.

Analyte detection using near-infrared fluorophores

Embodiments of near-infrared (NIR) dyes are disclosed, along with methods and kits for detecting analytes with the NIR dyes. The NIR dyes have a structure according to the general structure At least one of R/R, R/R, R/R, R/R, R/R, and/or R/Rtogether forms a substituted or unsubstituted cycloalkyl or aryl.

Near-infrared fluorescent dyes with large stokes shifts

Probes for selectively detecting compounds comprising a thiol group and an amino group ('thiols') are disclosed. Exemplary thiols include cysteine, homocysteine, and glutathione. Embodiments of the disclosed probes produce a detectable change in absorbance spectrum and/or emission spectrum when reacted with one or more thiols in solution. Methods and kits for performing the detection also are disclosed. The probes have a general formula where each bond depicted as '' is a single or double bond; R, R-Rand Rindependently are hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen; Ris an &#x3b1;,&#x3b2;-unsaturated aliphatic ester; Ris oxygen, sulfur, hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen, or Rand Rtogether form a cycloalkyl or aryl ring; Xis CH, S, NH, O, Se, Si(CH), Ge(CH), Sn(CH), or C(CH); and Xis CH, CH, N, NH, or CRwhere Ris aryl.

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Portland, OR, United States of America

Mark Allen Lowry