University of Iowa Research Foundation

Asl Analytical, Inc.

Ohio University

Mark Allen Arnold

Jonathon Todd Olesberg

Edwin John Koerperick

Christine Esther Evans

Gary Wray Small

Scott A Glazier

Gary W Small

Chris Coretsopoulos

Han Chuang

Gregory Allan Brower

A system and method for continuous, real-time process monitoring and control by means of near-infrared (NIR) spectroscopy provides analysis of static or flowing fluid streams which may range from clear to highly optically dense, including fluids primarily of aqueous composition. A NIR source passes through a wavelength selector to select one or more spectral segments, which are passed through the fluid stream at a fluid sampling interface and received at a sensor. A wavelength reference material is positioned in the optical path for calibration. Quantification of a plurality of characteristics or parameters of a fluid and suspended solids or cells contained therein may be performed. An all-solid-state implementation of the optical system ensures high robustness in laboratory and industrial settings.

Apparatus and method for automated process monitoring and control with near infrared spectroscopy

An optical sampling apparatus for disposable flexible bioprocessing vessels includes features for optical interrogation of the vessel contents by means of transmission or transflection spectroscopy. This optical interrogation allows for the determination of quantities and parameters of substances in fluids contained within the vessels during bioprocesses.

Near-infrared optical interfaces for disposable bioprocessing vessels

An optical probe with associated disposable polymer sheath for near-infrared optical interrogation of fluids within bioprocessing vessels by means of transmission or transflection spectroscopy provides for the determination of quantities and parameters of substances in fluids contained within bioprocessing vessels. Associated methods for use of the optical probe and associated sheath to determine quantities of substances in fluids and parameters of fluids during bioprocesses are provided.

Near-infrared optical probe and associated disposable sheath

An optical apparatus with a single-use, disposable fluid flow cartridge and cell and associated optical interface is employed in determining characteristics of a fluid and/or suspended materials or cells contained therein which are introduced into the apparatus. The optical interface communicates electromagnetic radiation from an optical instrument through the fluid within the cell and to an appropriate sensor within the optical instrument. The interaction of the electromagnetic radiation with the fluid is measured by the signal generated by the sensor. Fluid present within the cell may be static or flowing, allowing both discrete sample measurements and monitoring of continuous processes.

Optical cell with disposable fluid cartridge

Disclosed is an implantable microspectrometer for the reagentless optical detection of an analyte in a sample fluid. The microspectrometer comprises an optical sampling cell having a cell housing defining a fluid inlet port and a fluid outlet port, the fluid inlet port configured to receive an optical sampling fluid from a test subject; an electromagnetic radiation source in communication with a first portion of the optical sampling cell housing and configured to irradiate at least a portion of the optical sampling fluid with electromagnetic radiation; and an electromagnetic radiation detector in communication with a second portion of the optical sampling cell housing and configured to detect electromagnetic radiation emanating from the optical sampling cell. In use, the implantable microspectrometer can optically detect at least one parameter of an analyte contained within the optical sampling fluid in the absence of an added reagent.

Reagentless optical analyte detection system

A method for generating a net analyte signal calibration model for use in detecting and/or quantifying the amount of an analyte in a test subject. The net analyte signal can be generated by providing a set of in vivo infrared spectra for a test subject during a period in which an analyte concentration is essentially constant; calculating an optimal subspace of spectra that at least substantially describes all non-analyte dependent spectral variance in the in vivo spectra; providing a pure component infrared spectrum for the analyte; and calculating a net analyte signal spectrum from a data set comprising the optimal subspace spectra and the pure analyte spectrum. The net analyte signal calibration model can be used, for example, in measuring the concentration of analyte in a test subject, and/or for evaluating the analytical significance of an in vivo multivariate calibration model.

Method for generating a net analyte signal calibration model and uses thereof

Method and apparatus for non-invasive determination of physiological

An optical sensor is disclosed which uses a radioluminescent light source to supply the incident radiation for detecting a selected substance in a test medium. The radioluminescent source includes a beta emitting radio isotope which energizes a co-immobilized luminophore to release light in a given wavelength for a chemical sensor operation. The radioluminescent source is coupled with a sensing matrix for detecting and quantifying the analyte of interest. The sensing matrix produces a characteristic signal based on either absorbance or fluorescence which varies according to the concentration of the selected analyte in the sample. A photodetector measures the resulting optical signal from which the analyte concentration is determined.

Optical sensor with radioluminescent light source

Non-invasive measurements of physiological chemicals such as glucose are made using infrared radiation and a signal processing system that permits the construction of a device suited for home use. The level of a selected physiological chemical in a test subject is determined in a non-invasive and quantitative manner by a method comprising the steps of: (a) irradiating a portion of the test subject with near-infrared radiation such that the radiation is transmitted through or reflected from the test subject; (b) collecting data concerning the transmitted or reflected infrared radiation using a detector; (c) digitally filtering the collected data to isolate a portion of the data indicative of the physiological chemical; and (d) determining the amount of physiological chemical in the test subject by applying a defined mathematical model to the digitally filtered data. The data collected may be in the form of an absorbance spectrum, i.e., a representation of the variation in absorbance as a function of wavelength; or in the form of an interferogram, i.e., a representation of infrared light intensity as a function of the retardation of the moving mirror in the interferometer, and thus of time.

Method and apparatus for non-invasive detection of physiological

An improved phosphate selective membrane electrode using bis(p-chlorobenzyl)tin dichloride as the membrane active component. In addition to this tin compound, the membrane contains N,N-dimethylformamide (DMF), a strong complexing agent for tin compounds.

Phosphate selective membrane electrode

A novel ion-selective membrane electrode for the determination of phosphate anions. This device possesses an excellent selectivity for phosphate over many common anions such as sulfate, chloride, bromide, iodide, nitrate, and acetate. The unique feature of this electrode is the use of a di-substituted aryl tin compound as the membrane active material. The incorporation of either dibenzyltin dichloride or bis-p-methylbenzyltin dichloride in a plasticized poly(vinyl) chloride membrane results in a selective membrane electrode for phosphate.

Growing community of inventors

Iowa City, IA, United States of America

Mark Allen Arnold