Massachusetts Institute of Technology

Other

Houston Advanced Research Center

Baylor College of Medicine

Smiths Detection-edgewood, Inc.

Mark Alexander Hollis

James Douglas Harper

Richard Hart Mathews

Todd H Rider

Trina Rae Vian

Eric D Schwoebel

Martha Susan Petrovick

Bernadette Johnson

Frances E Nargi

Joseph John Lacirignola

Mark Hennessy

Kristine E Hogan

Daniel J Ehrlich

Michael E Hogan

Albert M Young

Shaun R Berry

Kirby B Nichols

Raymond S Uttaro

Rose M Joseph

Carl O Bozler

Kenneth Loren Beattie

John Shumaker

Timothy Stephens

Mitchell D Eggers

Ann Rundell

Linda Marie Mendenhall

Normand J Bergeron, Jr

Barry E Burke

Bernard B Kosicki

Dennis D Rathman

R Allen Murphy

Rajender S Varma

Arthur R Calawa

Frank W Smith

Laura T Bortolin

Allan Heff

Han Q Le

Vicky Diadiuk

Lalitha Parameswaran

Johanna Bobrow

Songeeta Palchaudhuri

Mitch D Eggers

Jeehwan Kim

Dirk Robert Englund

Michael W Geis

William D Goodhue

John C Schmidt

Paul William Juodawlkis

Joseph P Donnelly

Steven W Rabe

Reuel Bennett Swint

Eric Scott Clasen

Richard J Molnar

Chang-Lee Chen

Drew Chapman Brown

Travis Wade

Dominic Siriani

Christopher T Harris

Todd Harrison Rider

Richard H Mathews

Trina R Vian

Eric David Schwoebel

Eric Schwoebel

Richard Mathews

Joseph Lacirignola

Trina Vian

Frances Ellen Nargi

A buffer layer is employed to fabricate diamond membranes and allow reuse of diamond substrates. In this approach, diamond membranes are fabricated on the buffer layer, which in turn is disposed on a diamond substrate that is lattice-matched to the diamond membrane. The weak bonding between the buffer layer and the diamond substrate allows ready release of the fabricated diamond membrane. The released diamond membrane is transferred to another substrate to fabricate diamond devices, while the diamond substrate is reused for another fabrication.

Systems and methods for fabricating single-crystalline diamond membranes

An electro-optic modulator imparts the information contained in an electrical signal traveling along a transmission line onto an optical carrier by using signal-related variations in the electrical signal's voltage to modulate the refractive index or absorption in an electro-optic material through which the optical carrier propagates. For optimal bandwidth and modulation efficiency, the microwave and optical waves should be matched in velocity. However, conventional microwave transmission lines have a microwave velocity that is somewhat higher than the optical group velocity in typical optical waveguides. Tuning a microwave transmission line's capacitance reduces the microwave velocity, but also reduces the impedance below the 50&#x3a9; impedance of most microwave components. Conversely, tuning the microwave transmission line's inductance makes it possible to match the microwave velocity to the optical group velocity over bandwidths of 100 GHz or greater while maintaining a microwave impedance of 50&#x3a9;.

Inductance-tuned electro-optic modulators

The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.

Optoelectronic detection system

The invention described herein provides methods for the detection of target particles, such as pathogens, soluble antigens, nucleic acids, toxins, chemicals, plant pathogens, blood borne pathogens, bacteria, viruses and the like. Also described is an emittor cell comprising a receptor, wherein the receptor can be an antibody or an Fc receptor, and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more receptors on the emittor cell. Also provided are optoelectronic sensor devices for detecting a target particle in a sample, including in a plurality of samples.

Pathogen detection biosensor

The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.

An apparatus for preparing a nucleic acid component of a sample for amplification includes a porous support having an agent that deactivates a nucleic acid amplification inhibitor component of the sample. The apparatus further includes a housing with an opening and defining an interior. The interior of the housing is in fluid communication with the porous support, and at least a portion of a fluid directed through the opening is directed through at least a portion of the porous support. The apparatus also includes a magnetic substrate for separating nucleic acid from a sample.

Apparatus for isolating a nucleic acid from a sample

A method for preparing a nucleic acid component of a sample for amplification includes contacting the sample with a porous support that deactivates a nucleic acid amplification inhibitor component of the sample and directing a fluid through the porous support, whereby the nucleic acid component of the sample is directed through at least a portion of the porous support and is separated from the support, thereby preparing the nucleic acid component for amplification. The method can be conducted in an apparatus that includes a porous support having a component that deactivates a nucleic acid amplification inhibitor component of a sample contacting the porous support and a housing having an opening and defining an interior, said interior being in fluid communication with the porous support, whereby at least a portion of a fluid directed through the opening is directed through at least a portion of the porous support and separates at least a portion of a nucleic acid component of a sample contacting the porous support from the support, thereby preparing the nucleic acid component for amplification.

Apparatus and method for isolating a nucleic acid from a sample

A method and apparatus for identifying molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. Each test site includes a probe formed therein to bond with an associated target molecular structure. An electrical signal is applied to the test site and the electrical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.

Multi-site detection apparatus

A method and apparatus are disclosed for identifying molecular structures within a sample substance using a monolithic array of test sites formed on a substrate upon which the sample substance is applied. Each test site includes probes formed therein to bond with a predetermined target molecular structure or structures. A signal is applied to the test sites and certain electrical, mechanical and/or optical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.

Optical and electrical methods and apparatus for molecule detection

Growing community of inventors

Concord, MA, United States of America

Mark Alexander Hollis